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    Jkamp JNK1/MAPK8-associated membrane protein [ Mus musculus (house mouse) ]

    Gene ID: 104771, updated on 12-May-2024

    Summary

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    Official Symbol
    Jkampprovided by MGI
    Official Full Name
    JNK1/MAPK8-associated membrane proteinprovided by MGI
    Primary source
    MGI:MGI:1915057
    See related
    Ensembl:ENSMUSG00000005078 AllianceGenome:MGI:1915057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jamp; 1200003C05Rik; 2310047L11Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in brain; frontal bone; parietal bone; spinal cord; and trigeminal ganglion. Orthologous to human JKAMP (JNK1/MAPK8 associated membrane protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 22.4), whole brain E14.5 (RPKM 21.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Jkamp in Genome Data Viewer
    Location:
    12 C3; 12 30.2 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72132348..72148301)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72085548..72101527)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32433 Neighboring gene STARR-positive B cell enhancer ABC_E3055 Neighboring gene L-3-hydroxyproline dehydratase (trans-) Neighboring gene G protein-coupled receptor 135 Neighboring gene predicted gene 3225 Neighboring gene predicted gene, 19135 Neighboring gene coiled-coil domain containing 175 Neighboring gene STARR-seq mESC enhancer starr_32435 Neighboring gene zinc finger protein 146 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32436 Neighboring gene reticulon 1 Neighboring gene predicted gene, 52013

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation. Peng S, et al. Stem Cell Res Ther, 2021 Feb 12. PMID 33579371, Free PMC Article
    2. c-Jun NH(2) -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice. Chen Y, et al. Hepatology, 2020 May. PMID 31945188, Free PMC Article
    3. JAMP optimizes ERAD to protect cells from unfolded proteins. Tcherpakov M, et al. Mol Biol Cell, 2008 Nov. PMID 18784250, Free PMC Article
    4. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Kadoya T, et al. Mol Cell Biol, 2005 Oct. PMID 16166642, Free PMC Article
    5. Regional difference in microRNA regulation in the skull vault. Chen G, et al. Dev Dyn, 2019 Oct. PMID 31397024

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation.
      Title: JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation.
    2. c-Jun NH2 -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice.
      Title: c-Jun NH(2) -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice.
    3. JAMP is an important component for coordinated clearance of misfolded proteins from the endoplasmic reticulum.
      Title: JAMP optimizes ERAD to protect cells from unfolded proteins.
    4. JAMP is a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli [JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein]
      Title: JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    JNK1/MAPK8-associated membrane protein
    Names
    medulloblastoma antigen MU-MB-50.4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205067.1 → NP_001191996.1  JNK1/MAPK8-associated membrane protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK004555, CR974486
      Consensus CDS
      CCDS56844.1
      UniProtKB/Swiss-Prot
      Q8BI36
      Related
      ENSMUSP00000113744.2, ENSMUST00000117449.8
      Conserved Domains (1) summary
      pfam05571
      Location:3 → 294
      DUF766; Protein of unknown function (DUF766)

    2. NM_024205.2 → NP_077167.1  JNK1/MAPK8-associated membrane protein isoform 1

      See identical proteins and their annotated locations for NP_077167.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR974486
      Consensus CDS
      CCDS25967.1
      UniProtKB/Swiss-Prot
      B8JJ79, B8JJ80, Q8BI36, Q99LT2, Q9CUZ1
      Related
      ENSMUSP00000061370.9, ENSMUST00000057257.10
      Conserved Domains (1) summary
      pfam05571
      Location:9 → 300
      DUF766; Protein of unknown function (DUF766)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      72132348..72148301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246494.2 → XP_030102354.1  JNK1/MAPK8-associated membrane protein isoform X1

      Conserved Domains (1) summary
      pfam05571
      Location:4 → 295
      DUF766; Protein of unknown function (DUF766)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI36.2 GenPept UniProtKB/Swiss-Prot:Q8BI36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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