Vav1 vav 1 oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vav1provided by MGI
Official Full Name: vav 1 oncogeneprovided by MGI
Primary source: MGI:MGI:98923
See related: Ensembl:ENSMUSG00000034116 AllianceGenome:MGI:98923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vav; vav-T
Summary: Enables guanyl-nucleotide exchange factor activity and phosphorylation-dependent protein binding activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of natural killer cell mediated cytotoxicity. Located in cell-cell junction. Is expressed in several structures, including dorsal aorta; extraembryonic component; hemolymphoid system; pancreas; and reproductive system. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 27.9), spleen adult (RPKM 15.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.76 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57586080..57636236)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57279100..57329236)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation.
Title: Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation.
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Title: Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Vav1 accelerates Ras-driven lung cancer and modulates its tumor microenvironment.
Title: Vav1 accelerates Ras-driven lung cancer and modulates its tumor microenvironment.
Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.
Title: Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.
VAV1 mutations contribute to development of T-cell neoplasms in mice.
Title: VAV1 mutations contribute to development of T-cell neoplasms in mice.
Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Title: Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output.
Title: Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output.
MicroRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer's disease.
Title: MicroRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer's disease.
the depletion of the micro RNA processing enzyme dicer in Vav1-positive cells allows interfering with post-yolk sac microglia recruitment
Title: Decreased microglial numbers in Vav1-Cre(+):dicer knock-out mice suggest a second source of microglia beyond yolk sac macrophages.
this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1.
Title: Vav1 Regulates Mesenchymal Stem Cell Differentiation Decision Between Adipocyte and Chondrocyte via Sirt1.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (6)
Endonuclease-mediated (2)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_12285-12286:1005663674:1 (e-PCR)
- UniSTS:267396

MARC_12285-12286:1008002533:1 (e-PCR)
- UniSTS:267396

D83266 (e-PCR)
- UniSTS:160677

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	EXP Inferred from Experiment more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphorylation-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integrin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within reactive oxygen species metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: proto-oncogene vav

Names: p95vav; vav oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163815.1 → NP_001157287.1 proto-oncogene vav isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame segment of the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AK151214, AK152555, BY496946, CT010434

Consensus CDS

CCDS50158.1

UniProtKB/TrEMBL

E9PXI0, Q3UAV5

Related

ENSMUSP00000126694.3, ENSMUST00000169220.9

Conserved Domains (7) summary

cd10405
Location:641 → 743

SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins

cd11976
Location:762 → 815

SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein

cd11979
Location:572 → 634

SH3_VAV1_1; First Src homology 3 domain of VAV1 protein

cd00160
Location:171 → 347

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:361 → 484

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00130
Location:492 → 543

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl00030
Location:29 → 78

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
NM_001163816.1 → NP_001157288.1 proto-oncogene vav isoform 3

See identical proteins and their annotated locations for NP_001157288.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.

Source sequence(s)

BY139350, BY496946, CT010321, CT010434

Consensus CDS

CCDS50159.1

UniProtKB/TrEMBL

Q3U4K7, Q8VDU4

Related

ENSMUSP00000108491.5, ENSMUST00000112870.5

Conserved Domains (7) summary

cd11976
Location:747 → 800

SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein

cd11979
Location:596 → 658

SH3_VAV1_1; First Src homology 3 domain of VAV1 protein

cd00160
Location:195 → 371

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:385 → 508

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00130
Location:516 → 567

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl00030
Location:18 → 102

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl15255
Location:665 → 728

SH2; Src homology 2 (SH2) domain
NM_011691.4 → NP_035821.3 proto-oncogene vav isoform 1

See identical proteins and their annotated locations for NP_035821.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK152555, BY139350, BY496946, CT010434

Consensus CDS

CCDS28931.1

UniProtKB/Swiss-Prot

P27870, Q8BTV7

UniProtKB/TrEMBL

Q3U4K7, Q3U9E2

Related

ENSMUSP00000005889.10, ENSMUST00000005889.16

Conserved Domains (7) summary

cd10405
Location:665 → 767

SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins

cd11976
Location:786 → 839

SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein

cd11979
Location:596 → 658

SH3_VAV1_1; First Src homology 3 domain of VAV1 protein

cd00160
Location:195 → 371

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:385 → 508

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00130
Location:516 → 567

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl00030
Location:18 → 102

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...