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    Hs6st3 heparan sulfate 6-O-sulfotransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 50787, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hs6st3provided by MGI
    Official Full Name
    heparan sulfate 6-O-sulfotransferase 3provided by MGI
    Primary source
    MGI:MGI:1354960
    See related
    Ensembl:ENSMUSG00000053465 AllianceGenome:MGI:1354960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6OST3; HS6ST-3
    Summary
    Enables heparan sulfate 6-O-sulfotransferase activity. Acts upstream of or within heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; limb primordium; and sensory organ. Orthologous to human HS6ST3 (heparan sulfate 6-O-sulfotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 1.3), frontal lobe adult (RPKM 0.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hs6st3 in Genome Data Viewer
    Location:
    14 E4; 14 62.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119374902..120226864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (119137516..119869815)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119381910-119382076 Neighboring gene STARR-positive B cell enhancer mm9_chr14:119406665-119406966 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene predicted gene, 16835 Neighboring gene STARR-seq mESC enhancer starr_37667 Neighboring gene STARR-seq mESC enhancer starr_37668 Neighboring gene STARR-seq mESC enhancer starr_37669 Neighboring gene STARR-seq mESC enhancer starr_37670 Neighboring gene STARR-seq mESC enhancer starr_37671 Neighboring gene tera pseudogene Neighboring gene STARR-seq mESC enhancer starr_37673 Neighboring gene STARR-seq mESC enhancer starr_37675 Neighboring gene RIKEN cDNA 1700006F04 gene Neighboring gene CD24a antigen pseudogene Neighboring gene RIKEN cDNA 4930404K13 gene Neighboring gene predicted gene, 41249 Neighboring gene STARR-seq mESC enhancer starr_37676 Neighboring gene STARR-seq mESC enhancer starr_37677 Neighboring gene STARR-seq mESC enhancer starr_37678 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37680 Neighboring gene oxoglutarate (alpha-ketoglutarate) receptor 1 Neighboring gene 60S ribosomal protein L39 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin. Anower-E-Khuda MF, et al. J Biol Chem, 2013 Feb 8. PMID 23223449, Free PMC Article
    2. Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation. Do AT, et al. J Biol Chem, 2006 Mar 3. PMID 16326709
    3. Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis. Sedita J, et al. Dev Dyn, 2004 Dec. PMID 15499561
    4. Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases. Smeds E, et al. Biochem J, 2003 Jun 1. PMID 12611590, Free PMC Article
    5. Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice. Conway CD, et al. J Anat, 2011 Dec. PMID 21951307, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.
      Title: Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.
    2. 6OST3 appears at later stages and in a more restricted manner than its isoenzymes during development
      Title: Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144859, MGC144860

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 6-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan-sulfate 6-O-sulfotransferase 3
    NP_056635.2
    XP_006519301.1
    XP_011243415.1
    XP_036014643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015820.3 → NP_056635.2  heparan-sulfate 6-O-sulfotransferase 3

      See identical proteins and their annotated locations for NP_056635.2

      Status: VALIDATED

      Source sequence(s)
      AB024567, AK139324, BC117529
      Consensus CDS
      CCDS27339.1
      UniProtKB/Swiss-Prot
      Q148Q1, Q9QYK4
      Related
      ENSMUSP00000070394.4, ENSMUST00000065904.5
      Conserved Domains (1) summary
      pfam03567
      Location:143 → 409
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      119374902..120226864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519238.5 → XP_006519301.1  heparan-sulfate 6-O-sulfotransferase 3 isoform X3

      UniProtKB/TrEMBL
      Q3UTM4
      Conserved Domains (1) summary
      cl22970
      Location:143 → 225
      Sulfotransfer_2; Sulfotransferase family

    2. XM_036158750.1 → XP_036014643.1  heparan-sulfate 6-O-sulfotransferase 3 isoform X1

      UniProtKB/TrEMBL
      Q3UTM4
      Conserved Domains (1) summary
      cl22970
      Location:143 → 225
      Sulfotransfer_2; Sulfotransferase family

    3. XM_011245113.4 → XP_011243415.1  heparan-sulfate 6-O-sulfotransferase 3 isoform X2

      UniProtKB/TrEMBL
      Q3UTM4
      Conserved Domains (1) summary
      cl22970
      Location:143 → 225
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYK4.2 GenPept UniProtKB/Swiss-Prot:Q9QYK4

    Gene LinkOut

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