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    Nupr2 nuclear protein transcriptional regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 69034, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nupr2provided by MGI
    Official Full Name
    nuclear protein transcriptional regulator 2provided by MGI
    Primary source
    MGI:MGI:1923099
    See related
    Ensembl:ENSMUSG00000095789 AllianceGenome:MGI:1923099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nupr1l; 1810010E01Rik; 4930579G22Rik
    Summary
    Predicted to be involved in several processes, including cellular response to starvation; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human NUPR2 (nuclear protein 2, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 183.7) and genital fat pad adult (RPKM 7.7) See more
    Orthologs
    human all
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    Genomic context

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    See Nupr2 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129937381..129942629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129908540..129913788)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5 Neighboring gene STARR-seq mESC enhancer starr_14464 Neighboring gene STARR-positive B cell enhancer ABC_E1308 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_14467 Neighboring gene STARR-seq mESC enhancer starr_14468 Neighboring gene glucuronidase, beta Neighboring gene STARR-positive B cell enhancer ABC_E10355 Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear protein 2
    Names
    nuclear protein transcriptional regulator 1 like
    nuclear transcriptional regulator 1-like protein
    nuclear transcriptional regulator protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359308.1 → NP_001346237.1  nuclear protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC164071, AK016320
      Consensus CDS
      CCDS51654.1
      UniProtKB/Swiss-Prot
      Q3UXQ0, Q497P3, Q9D923
      Related
      ENSMUSP00000142125.2, ENSMUST00000194521.2
      Conserved Domains (1) summary
      pfam10195
      Location:31 → 84
      Phospho_p8; DNA-binding nuclear phosphoprotein p8

    2. NM_026916.3 → NP_081192.2  nuclear protein 2

      See identical proteins and their annotated locations for NP_081192.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC100444, CJ051706, EL963130
      Consensus CDS
      CCDS51654.1
      UniProtKB/Swiss-Prot
      Q3UXQ0, Q497P3, Q9D923
      Related
      ENSMUSP00000141660.2, ENSMUST00000195766.6
      Conserved Domains (1) summary
      pfam10195
      Location:31 → 84
      Phospho_p8; DNA-binding nuclear phosphoprotein p8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129937381..129942629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q497P3.1 GenPept UniProtKB/Swiss-Prot:Q497P3

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