Apom apolipoprotein M [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apomprovided by RGD
Official Full Name: apolipoprotein Mprovided by RGD
Primary source: RGD:620773
See related: AllianceGenome:RGD:620773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable antioxidant activity; lipid transporter activity; and phospholipid binding activity. Involved in response to glucose. Located in extracellular space. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2710.9) and Kidney (RPKM 2269.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3695618..3698218)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3690950..3693550)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5120473..5123073, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway.
Title: Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway.
ApoM occurrence in urine may be considered to be a biomarker of acute renal injury.
Title: Urinary apolipoprotein M could be used as a biomarker of acute renal injury: an ischemia-reperfusion injury model of kidney in rat.
ApoM levels and expression in rats rendered hyperglycemic by short-term glucose infusion, was investigated.
Title: Hyperglycemia down-regulates apolipoprotein M expression in vivo and in vitro.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142043 (e-PCR)
- UniSTS:224033

Apom (e-PCR), detects polymorphism
- UniSTS:506682

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasma lipoprotein oxidation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasma lipoprotein oxidation	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within reverse cholesterol transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of discoidal high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of discoidal high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein M

Names: apo-M; protein Px

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019373.2 → NP_062246.1 apolipoprotein M precursor

See identical proteins and their annotated locations for NP_062246.1

Status: VALIDATED

Source sequence(s)

BC089807, BX883045

UniProtKB/Swiss-Prot

P14630, Q5EBB9, Q9QXI9

UniProtKB/TrEMBL

A6KTU9

Conserved Domains (1) summary

cl21528
Location:1 → 189

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family