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    Cmc4 C-X9-C motif containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 105886298, updated on 13-Mar-2024

    Summary

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    Official Symbol
    Cmc4provided by MGI
    Official Full Name
    C-X9-C motif containing 4provided by MGI
    Primary source
    MGI:MGI:5637812
    See related
    Ensembl:ENSMUSG00000090110 AllianceGenome:MGI:5637812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtcp1nb; p8MTCP1
    Summary
    Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human CMC4 (C-X9-C motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.2), CNS E14 (RPKM 5.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cmc4 in Genome Data Viewer
    Location:
    X A7.3; X
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (74448452..74460190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (75404846..75416584, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene predicted gene 8522 Neighboring gene STARR-seq mESC enhancer starr_47381 Neighboring gene STARR-seq mESC enhancer starr_47382 Neighboring gene FUN14 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11683 Neighboring gene mature T cell proliferation 1 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. Madani A, et al. Blood, 1996 Mar 1. PMID 8634440
    2. The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. Soulier J, et al. Oncogene, 1994 Dec. PMID 7970717
    3. The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein. Madani A, et al. Oncogene, 1995 Jun 1. PMID 7784073
    4. The murine Tcl1 oncogene: embryonic and lymphoid cell expression. Narducci MG, et al. Oncogene, 1997 Aug 18. PMID 9285687
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC170438, MGC170439

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cx9C motif-containing protein 4
    Names
    C-x(9)-C motif containing 4
    MTCP-1 type A
    mature T-cell proliferation 1 neighbor protein
    mature T-cell proliferation-1 type A
    protein p8 MTCP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294277.1 → NP_001281206.1  cx9C motif-containing protein 4

      See identical proteins and their annotated locations for NP_001281206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL671860, AL731844
      Consensus CDS
      CCDS41030.1
      UniProtKB/Swiss-Prot
      Q61908
      UniProtKB/TrEMBL
      A3KGA5
      Related
      ENSMUSP00000117381.3, ENSMUST00000149863.3
      Conserved Domains (1) summary
      pfam08991
      Location:6 → 59
      MTCP1; Mature-T-Cell Proliferation I type

    2. NM_010839.6 → NP_034969.1  cx9C motif-containing protein 4

      See identical proteins and their annotated locations for NP_034969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL671860, AL731844, DV655269
      Consensus CDS
      CCDS41030.1
      UniProtKB/Swiss-Prot
      Q61908
      UniProtKB/TrEMBL
      A3KGA5
      Related
      ENSMUSP00000033543.8, ENSMUST00000033543.14
      Conserved Domains (1) summary
      pfam08991
      Location:6 → 59
      MTCP1; Mature-T-Cell Proliferation I type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      74448452..74460190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61908.1 GenPept UniProtKB/Swiss-Prot:Q61908

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials