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    Rnf152 ring finger protein 152 [ Mus musculus (house mouse) ]

    Gene ID: 320311, updated on 14-May-2024

    Summary

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    Official Symbol
    Rnf152provided by MGI
    Official Full Name
    ring finger protein 152provided by MGI
    Primary source
    MGI:MGI:2443787
    See related
    Ensembl:ENSMUSG00000047496 AllianceGenome:MGI:2443787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930029B02Rik
    Summary
    Predicted to enable small GTPase binding activity and ubiquitin protein ligase activity. Involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be located in lysosome. Predicted to be integral component of organelle membrane. Predicted to be active in lysosomal membrane. Is expressed in diencephalon lateral wall mantle layer; diencephalon mantle layer; hypothalamus mantle layer; hypothalamus ventricular layer; and thalamus mantle layer. Orthologous to human RNF152 (ring finger protein 152). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 5.5), whole brain E14.5 (RPKM 4.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf152 in Genome Data Viewer
    Location:
    1 E2.1; 1 49.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105204642..105284665, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105276917..105356991, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cadherin 20 Neighboring gene STARR-seq mESC enhancer starr_01837 Neighboring gene predicted gene, 53576 Neighboring gene STARR-seq mESC enhancer starr_01838 Neighboring gene STARR-seq mESC enhancer starr_01839 Neighboring gene STARR-seq mESC enhancer starr_01840 Neighboring gene predicted gene, 41925 Neighboring gene predicted gene 29012 Neighboring gene STARR-seq mESC enhancer starr_01841 Neighboring gene predicted gene, 17634 Neighboring gene predicted gene 28403 Neighboring gene predicted gene, 57564

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. Wu Y, et al. PLoS One, 2018. PMID 29300766, Free PMC Article
    2. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Deng L, et al. Cell Res, 2019 Feb. PMID 30514904, Free PMC Article
    3. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization. Xiong MG, et al. EMBO Rep, 2020 Mar 4. PMID 31930677, Free PMC Article
    4. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Deng L, et al. Mol Cell, 2015 Jun 4. PMID 25936802
    5. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization.
      Title: RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF152
    Names
    RING-type E3 ubiquitin transferase RNF152
    NP_001153840.1
    NP_848894.1
    XP_017176696.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160368.1 → NP_001153840.1  E3 ubiquitin-protein ligase RNF152

      See identical proteins and their annotated locations for NP_001153840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC162907, CJ112559
      Consensus CDS
      CCDS15204.1
      UniProtKB/Swiss-Prot
      Q0VF67, Q8BG47
      Related
      ENSMUSP00000128632.2, ENSMUST00000172299.2
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    2. NM_178779.4 → NP_848894.1  E3 ubiquitin-protein ligase RNF152

      See identical proteins and their annotated locations for NP_848894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC162907, AK035832, CJ112559
      Consensus CDS
      CCDS15204.1
      UniProtKB/Swiss-Prot
      Q0VF67, Q8BG47
      Related
      ENSMUSP00000050103.6, ENSMUST00000058688.7
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      105204642..105284665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321207.3 → XP_017176696.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      Q0VF67, Q8BG47
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG47.1 GenPept UniProtKB/Swiss-Prot:Q8BG47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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