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    Crtac1 cartilage acidic protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171438, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Crtac1provided by RGD
    Official Full Name
    cartilage acidic protein 1provided by RGD
    Primary source
    RGD:621085
    See related
    Ensembl:ENSRNOG00000015220 AllianceGenome:RGD:621085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    W307
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in axonal fasciculation. Predicted to act upstream of or within negative regulation of receptor binding activity and olfactory bulb development. Predicted to be located in growth cone. Orthologous to human CRTAC1 (cartilage acidic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 74.8), Adrenal (RPKM 7.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crtac1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (251040963..251182920, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (241091679..241233677, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261527009..261669614, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547392 Neighboring gene golgin A7 family, member B Neighboring gene microRNA 3085 Neighboring gene uncharacterized LOC120100039 Neighboring gene R3H domain and coiled-coil containing 1-like Neighboring gene lysyl oxidase-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Sato Y, et al. Science, 2011 Aug 5. PMID 21817055, Free PMC Article
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonal fasciculation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within olfactory bulb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cartilage acidic protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134401.2 → NP_599228.2  cartilage acidic protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      BC089944, CB692164, CO401990, DV714989
      UniProtKB/TrEMBL
      A0A096MJG4, F1LQP7
      Related
      ENSRNOP00000020568.5, ENSRNOT00000020568.7
      Conserved Domains (3) summary
      pfam07593
      Location:461 → 513
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:560 → 606
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:300 → 364
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      251040963..251182920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231385.5 → XP_006231447.1  cartilage acidic protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A096MJG4
      Conserved Domains (2) summary
      pfam07593
      Location:461 → 522
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:300 → 364
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    2. XM_017588738.3 → XP_017444227.1  cartilage acidic protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A096MJG4

    3. XM_063276946.1 → XP_063133016.1  cartilage acidic protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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