Emp1 epithelial membrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Emp1provided by RGD
Official Full Name: epithelial membrane protein 1provided by RGD
Primary source: RGD:2552
See related: Ensembl:ENSRNOG00000008676 AllianceGenome:RGD:2552
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TMP; CL-20; EMP-1; ENP1MR
Summary: Predicted to be involved in bleb assembly and cell death. Located in plasma membrane. Orthologous to human EMP1 (epithelial membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 353.9), Lung (RPKM 341.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q43

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (169931537..169964366)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (168212901..168233039)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (169161076..169181967)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This report is the first to indicate EMP-1 to be a junctional protein in the liver.
Title: EMP-1 is a junctional protein in a liver stem cell line and in the liver.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in bleb assembly	IEA Inferred from Electronic Annotation more info
involved_in bleb assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: epithelial membrane protein 1

Names: tumor-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012843.2 → NP_036975.1 epithelial membrane protein 1

See identical proteins and their annotated locations for NP_036975.1

Status: PROVISIONAL

Source sequence(s)

BC087031

UniProtKB/Swiss-Prot

P54848

UniProtKB/TrEMBL

A0A8I5ZRF3, A6IMG6

Related

ENSRNOP00000011580.3, ENSRNOT00000011580.7

Conserved Domains (1) summary

pfam00822
Location:1 → 154

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

169931537..169964366

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285590.1 → XP_063141660.1 epithelial membrane protein 1 isoform X1

UniProtKB/Swiss-Prot

P54848

UniProtKB/TrEMBL

A6IMG6
XM_063285589.1 → XP_063141659.1 epithelial membrane protein 1 isoform X1

UniProtKB/Swiss-Prot

P54848

UniProtKB/TrEMBL

A6IMG6
XM_063285588.1 → XP_063141658.1 epithelial membrane protein 1 isoform X1

UniProtKB/Swiss-Prot

P54848

UniProtKB/TrEMBL

A6IMG6