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    Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288480, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aimp2provided by RGD
    Official Full Name
    aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by RGD
    Primary source
    RGD:1560787
    See related
    Ensembl:ENSRNOG00000001044 AllianceGenome:RGD:1560787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Jtv1
    Summary
    Predicted to enable molecular adaptor activity. Acts upstream of or within positive regulation of neuron death. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 220.6), Heart (RPKM 126.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aimp2 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15814854..15824432)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10701194..10710772)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12738784..12748345)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B Neighboring gene small nucleolar RNA SNORA51 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Ko HS, et al. Proc Natl Acad Sci U S A, 2010 Sep 21. PMID 20823226, Free PMC Article
    2. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Yannay-Cohen N, et al. Mol Cell, 2009 Jun 12. PMID 19524539
    3. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Kim MJ, et al. Nat Genet, 2003 Jul. PMID 12819782
    4. Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells. Kaminska M, et al. J Biol Chem, 2009 May 15. PMID 19289464, Free PMC Article
    5. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. Kaminska M, et al. J Biol Chem, 2009 Mar 6. PMID 19131329

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125271

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in type II pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within type II pneumocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Names
    JTV1
    multisynthase complex auxiliary component p38
    multisynthetase complex auxiliary component p38
    protein JTV-1
    rCG42778-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037348.1 → NP_001032425.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2

      See identical proteins and their annotated locations for NP_001032425.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107947
      UniProtKB/Swiss-Prot
      Q32PX2
      UniProtKB/TrEMBL
      A0A8L2PZG3
      Related
      ENSRNOP00000001379.3, ENSRNOT00000001379.6
      Conserved Domains (2) summary
      cd03200
      Location:214 → 309
      GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
      pfam16780
      Location:1 → 33
      AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15814854..15824432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248863.5 → XP_006248925.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2PZG3
      Conserved Domains (1) summary
      cd03200
      Location:174 → 269
      GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PX2.1 GenPept UniProtKB/Swiss-Prot:Q32PX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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