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    Tnfrsf23 tumor necrosis factor receptor superfamily, member 23 [ Mus musculus (house mouse) ]

    Gene ID: 79201, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Tnfrsf23provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 23provided by MGI
    Primary source
    MGI:MGI:1930269
    See related
    Ensembl:ENSMUSG00000037613 AllianceGenome:MGI:1930269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SOB; mSOB; Tnfrh1; TNFRSFH23; Tnfrsf1al1; mDcTRAILR1
    Summary
    This gene encodes a member of the tumor necrosis factor superfamily of proteins. The encoded receptor has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. This gene shows elevated expression in mice with diet-induced fatty liver disease. This gene and other family members are present in a gene cluster on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in placenta adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 2.1) and 27 other tissues See more
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    Genomic context

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    See Tnfrsf23 in Genome Data Viewer
    Location:
    7 F5; 7 88.28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143219544..143239836, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143665807..143686436, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 26 Neighboring gene RIKEN cDNA E230032D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E6618 Neighboring gene STARR-seq mESC enhancer starr_20534 Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene STARR-positive B cell enhancer ABC_E10486 Neighboring gene oxysterol binding protein-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762 Neighboring gene MAS-related GPR, member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. Farrell GC, et al. J Gastroenterol Hepatol, 2009 Mar. PMID 19226377
    2. A genomic reservoir for Tnfrsf genes is developmentally regulated and imprinted in the mouse. de la Casa Esperón E, et al. Epigenetics, 2012 Jun 1. PMID 22595876, Free PMC Article
    3. The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. Clark L, et al. BMC Genet, 2002 Jun 27. PMID 12102730, Free PMC Article
    4. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
    5. Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. Mahy NL, et al. J Cell Biol, 2002 Dec 9. PMID 12473685, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Apoptosis in experimental non-alcoholic steatohepatitis is associated with p53 activation and TRAIL receptor expression.
      Title: Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.
    2. The Tnfrh1 gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface.
      Title: The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123882, MGC123883

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation-induced cell death of T cells IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in necroptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 23
    Names
    TNF receptor family member SOB
    TNF receptor homolog 1
    decoy TRAIL receptor 1
    tumor necrosis factor receptor p60 homolog 1
    tumor necrosis factor receptor superfamily, member 1a-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308111.1 → NP_001295040.1  tumor necrosis factor receptor superfamily member 23 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001295040.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC068006, BG077775, BP768617, BY036522, BY201915
      Consensus CDS
      CCDS85480.1
      UniProtKB/TrEMBL
      A0A140LIU0
      Related
      ENSMUSP00000146956.2, ENSMUST00000208017.2
      Conserved Domains (1) summary
      cl22855
      Location:38 → 98
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    2. NM_024290.4 → NP_077252.2  tumor necrosis factor receptor superfamily member 23 isoform 1 precursor

      See identical proteins and their annotated locations for NP_077252.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC068006, BG077775, BP768617, BY036522, BY201915
      Consensus CDS
      CCDS22044.1
      UniProtKB/Swiss-Prot
      Q8VHC0, Q9ER63
      UniProtKB/TrEMBL
      Q3U3F7
      Related
      ENSMUSP00000116742.2, ENSMUST00000152703.2
      Conserved Domains (1) summary
      cd15837
      Location:38 → 155
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    RNA

    1. NR_131763.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC068006, BG077775, BP768617, BY036522, BY201915
      Related
      ENSMUST00000035742.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143219544..143239836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508661.4 → XP_006508724.1  tumor necrosis factor receptor superfamily member 23 isoform X3

      Conserved Domains (1) summary
      cd15837
      Location:38 → 155
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    2. XM_036153591.1 → XP_036009484.1  tumor necrosis factor receptor superfamily member 23 isoform X4

      Conserved Domains (1) summary
      cd15837
      Location:38 → 155
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    3. XM_036153590.1 → XP_036009483.1  tumor necrosis factor receptor superfamily member 23 isoform X2

      Conserved Domains (1) summary
      cd15837
      Location:38 → 155
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    4. XM_006508660.5 → XP_006508723.1  tumor necrosis factor receptor superfamily member 23 isoform X1

      Conserved Domains (1) summary
      cd15837
      Location:38 → 155
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    RNA

    1. XR_004934224.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER63.2 GenPept UniProtKB/Swiss-Prot:Q9ER63

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