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    Shld2 shieldin complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 75698, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Shld2provided by MGI
    Official Full Name
    shieldin complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1922948
    See related
    Ensembl:ENSMUSG00000041471 AllianceGenome:MGI:1922948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam35a; 3110001K24Rik
    Summary
    Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SHLD2 (shieldin complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 3.2), liver adult (RPKM 2.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Shld2 in Genome Data Viewer
    Location:
    14 B; 14 20.8 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33958905..34032528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34236948..34310651, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36364 Neighboring gene VISTA enhancer mm340 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene synaptotagmin XV Neighboring gene STARR-seq mESC enhancer starr_36366 Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36368 Neighboring gene STARR-seq mESC enhancer starr_36370 Neighboring gene STARR-seq mESC enhancer starr_36372 Neighboring gene STARR-seq mESC enhancer starr_36373 Neighboring gene glutamate dehydrogenase 1 Neighboring gene B-cell CLL/lymphoma 7C pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis. Mirman Z, et al. Nat Cell Biol, 2022 Jan. PMID 35027730, Free PMC Article
    2. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
    3. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Gupta R, et al. Cell, 2018 May 3. PMID 29656893, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somatic diversification of immunoglobulins involved in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in telomere maintenance in response to DNA damage NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shieldin complex subunit 2
    Names
    RINN1-REV7-interacting novel NHEJ regulator 2
    family with sequence similarity 35, member A
    protein FAM35A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360074.1 → NP_001347003.1  shieldin complex subunit 2

      Status: VALIDATED

      Source sequence(s)
      AC154738, AK149442, BE630700, BE648821, BE848901, BF467362, BQ829235, BU756157
      Consensus CDS
      CCDS36874.1
      UniProtKB/Swiss-Prot
      E9Q8K3, Q3UEN2
      UniProtKB/TrEMBL
      B7ZMV3
      Conserved Domains (1) summary
      pfam15793
      Location:695 → 866
      FAM35_C; Protein family FAM35, C-terminal

    2. NM_029389.3 → NP_083665.2  shieldin complex subunit 2

      See identical proteins and their annotated locations for NP_083665.2

      Status: VALIDATED

      Source sequence(s)
      AI451789, AK149442, BF467362, BU756157, CD547520
      Consensus CDS
      CCDS36874.1
      UniProtKB/Swiss-Prot
      E9Q8K3, Q3UEN2
      UniProtKB/TrEMBL
      B7ZMV3
      Related
      ENSMUSP00000107548.2, ENSMUST00000111917.3
      Conserved Domains (1) summary
      pfam15793
      Location:695 → 866
      FAM35_C; Protein family FAM35, C-terminal

    RNA

    1. NR_153399.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154738, AC160930, AK149442, BE630700, BE848901, BF467362, BQ829235, BU756157

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33958905..34032528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519652.5 → XP_006519715.1  shieldin complex subunit 2 isoform X4

      See identical proteins and their annotated locations for XP_006519715.1

      Conserved Domains (1) summary
      pfam15793
      Location:143 → 314
      FAM35_C; Protein family FAM35, C-terminal

    2. XM_017316219.3 → XP_017171708.1  shieldin complex subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam15793
      Location:143 → 314
      FAM35_C; Protein family FAM35, C-terminal

    3. XM_011245218.4 → XP_011243520.1  shieldin complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      B7ZMV3
      Conserved Domains (1) summary
      pfam15793
      Location:659 → 830
      FAM35_C; Protein family FAM35, C-terminal

    4. XM_006519650.5 → XP_006519713.1  shieldin complex subunit 2 isoform X3

      Conserved Domains (1) summary
      pfam15793
      Location:178 → 349
      FAM35_C; Protein family FAM35, C-terminal

    5. XM_006519651.4 → XP_006519714.1  shieldin complex subunit 2 isoform X4

      See identical proteins and their annotated locations for XP_006519714.1

      Conserved Domains (1) summary
      pfam15793
      Location:143 → 314
      FAM35_C; Protein family FAM35, C-terminal

    6. XM_011245216.4 → XP_011243518.1  shieldin complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011243518.1

      UniProtKB/Swiss-Prot
      E9Q8K3, Q3UEN2
      UniProtKB/TrEMBL
      B7ZMV3
      Conserved Domains (1) summary
      pfam15793
      Location:695 → 866
      FAM35_C; Protein family FAM35, C-terminal

    7. XM_006519646.5 → XP_006519709.1  shieldin complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006519709.1

      UniProtKB/Swiss-Prot
      E9Q8K3, Q3UEN2
      UniProtKB/TrEMBL
      B7ZMV3
      Conserved Domains (1) summary
      pfam15793
      Location:695 → 866
      FAM35_C; Protein family FAM35, C-terminal

    8. XM_006519648.5 → XP_006519711.1  shieldin complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006519711.1

      UniProtKB/Swiss-Prot
      E9Q8K3, Q3UEN2
      UniProtKB/TrEMBL
      B7ZMV3
      Conserved Domains (1) summary
      pfam15793
      Location:695 → 866
      FAM35_C; Protein family FAM35, C-terminal

    9. XM_006519645.5 → XP_006519708.1  shieldin complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006519708.1

      UniProtKB/Swiss-Prot
      E9Q8K3, Q3UEN2
      UniProtKB/TrEMBL
      B7ZMV3
      Conserved Domains (1) summary
      pfam15793
      Location:695 → 866
      FAM35_C; Protein family FAM35, C-terminal

    RNA

    1. XR_001781163.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UEN2.2 GenPept UniProtKB/Swiss-Prot:Q3UEN2

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