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    Ak2 adenylate kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24184, updated on 2-May-2024

    Summary

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    Official Symbol
    Ak2provided by RGD
    Official Full Name
    adenylate kinase 2provided by RGD
    Primary source
    RGD:2077
    See related
    Ensembl:ENSRNOG00000000122 AllianceGenome:RGD:2077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables adenylate kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including oxidative phosphorylation; purine nucleotide metabolic process; and response to thyroid hormone. Located in cytosol; mitochondrial intermembrane space; and nucleus. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 732.2), Kidney (RPKM 532.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ak2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146609469..146649008)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141308650..141364633)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147185474..147204050)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 62 Neighboring gene antizyme inhibitor 2 Neighboring gene ring finger protein 7-like Neighboring gene uncharacterized LOC102551249 Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats. Peng X, et al. J Mol Neurosci, 2012 May. PMID 22246993
    2. Distinct behaviors of adenylate kinase and cytochrome c observed following induction of mitochondrial permeability transition by Ca(2+) in the absence of respiratory substrate. Yamamoto T, et al. J Bioenerg Biomembr, 2008 Dec. PMID 19139979
    3. Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Eimre M, et al. Biochim Biophys Acta, 2008 Jun. PMID 18423391
    4. Evidence of a new phosphoryl transfer system in nucleotide metabolism. Vannoni D, et al. FEBS J, 2009 Jan. PMID 19049516
    5. Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne dystrophic serum aberrant adenylate kinase. Hamada M, et al. J Biol Chem, 1982 Nov 10. PMID 6182143

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AK2 participates in the pathophysiological process of temporal lobe epilepsy.
      Title: Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    contributes_to nucleobase-containing compound kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in AMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dATP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxidative phosphorylation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to thyroid hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm mitochondrial sheath ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 2, mitochondrial
    Names
    AK 2
    ATP-AMP transphosphorylase 2
    ATP:AMP phosphotransferase
    adenylate monophosphate kinase
    NP_001029139.1
    NP_112248.2
    XP_038965181.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033967.2 → NP_001029139.1  adenylate kinase 2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001029139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC061727, CO570724
      UniProtKB/Swiss-Prot
      P29410, Q6P7C6
      UniProtKB/TrEMBL
      A0A0G2JSG6, A6ISG7
      Related
      ENSRNOP00000000134.2, ENSRNOT00000000134.5
      Conserved Domains (2) summary
      PRK00279
      Location:17 → 229
      adk; adenylate kinase; Reviewed
      cd01428
      Location:17 → 219
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    2. NM_030986.2 → NP_112248.2  adenylate kinase 2, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_112248.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AA956036, CO570724
      UniProtKB/Swiss-Prot
      P29410, Q6P7C6
      UniProtKB/TrEMBL
      A6ISG8
      Conserved Domains (2) summary
      PRK00279
      Location:17 → 229
      adk; adenylate kinase; Reviewed
      cd01428
      Location:17 → 219
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      146609469..146649008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109253.2 → XP_038965181.1  adenylate kinase 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK00279
      Location:1 → 181
      adk; adenylate kinase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29410.2 GenPept UniProtKB/Swiss-Prot:P29410

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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