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    Hhipl2 hedgehog interacting protein-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 78772, updated on 12-May-2024

    Summary

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    Official Symbol
    Hhipl2provided by MGI
    Official Full Name
    hedgehog interacting protein-like 2provided by MGI
    Primary source
    MGI:MGI:1926022
    See related
    Ensembl:ENSMUSG00000053461 AllianceGenome:MGI:1926022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hhip3; 4930507C10Rik
    Summary
    Predicted to enable catalytic activity. Predicted to be located in extracellular region. Orthologous to human HHIPL2 (HHIP like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 1.8), thymus adult (RPKM 0.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hhipl2 in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183195395..183217962)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183414463..183437053)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, A Neighboring gene predicted gene, 33973 Neighboring gene STARR-seq mESC enhancer starr_03295 Neighboring gene predicted gene, 39724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics on HHIP family orthologs. Katoh Y, et al. Int J Mol Med, 2006 Feb. PMID 16391842
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HHIP-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308052.1 → NP_001294981.1  HHIP-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001294981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon which results in a distinct 5' UTR and the use of a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK019671, AW909171
      Consensus CDS
      CCDS78765.1
      UniProtKB/Swiss-Prot
      Q9D2G9
      Related
      ENSMUSP00000142121.2, ENSMUST00000192527.2
      Conserved Domains (1) summary
      pfam07995
      Location:1 → 243
      GSDH; Glucose / Sorbosone dehydrogenase

    2. NM_030175.5 → NP_084451.2  HHIP-like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_084451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AEKQ02108034, AK019671, AW909171
      Consensus CDS
      CCDS56664.1
      UniProtKB/Swiss-Prot
      Q9D2G9
      Related
      ENSMUSP00000070719.5, ENSMUST00000065900.10
      Conserved Domains (2) summary
      pfam03024
      Location:43 → 181
      Folate_rec; Folate receptor family
      pfam07995
      Location:215 → 463
      GSDH; Glucose / Sorbosone dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      183195395..183217962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243698.1 → XP_030099558.1  HHIP-like protein 2 isoform X2

      Conserved Domains (2) summary
      pfam03024
      Location:12 → 97
      Folate_rec; Folate receptor family
      cl26817
      Location:131 → 379
      GSDH; Glucose / Sorbosone dehydrogenase

    2. XM_011249733.3 → XP_011248035.1  HHIP-like protein 2 isoform X1

      Conserved Domains (2) summary
      pfam03024
      Location:43 → 181
      Folate_rec; Folate receptor family
      cl26817
      Location:215 → 469
      GSDH; Glucose / Sorbosone dehydrogenase

    3. XM_011249736.4 → XP_011248038.1  HHIP-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011248038.1

      Conserved Domains (1) summary
      cl26817
      Location:1 → 249
      GSDH; Glucose / Sorbosone dehydrogenase

    4. XM_011249737.4 → XP_011248039.1  HHIP-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011248039.1

      Conserved Domains (1) summary
      cl26817
      Location:1 → 249
      GSDH; Glucose / Sorbosone dehydrogenase

    RNA

    1. XR_880811.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2G9.2 GenPept UniProtKB/Swiss-Prot:Q9D2G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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