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    Ldlrad3 low density lipoprotein receptor class A domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 241576, updated on 7-May-2024

    Summary

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    Official Symbol
    Ldlrad3provided by MGI
    Official Full Name
    low density lipoprotein receptor class A domain containing 3provided by MGI
    Primary source
    MGI:MGI:2138856
    See related
    Ensembl:ENSMUSG00000048058 AllianceGenome:MGI:2138856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrad3; 6430500P08
    Summary
    Enables amyloid-beta binding activity. Acts upstream of or within receptor-mediated endocytosis and regulation of protein processing. Located in plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and gut. Orthologous to human LDLRAD3 (low density lipoprotein receptor class A domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 16.1), CNS E11.5 (RPKM 7.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ldlrad3 in Genome Data Viewer
    Location:
    2 E2; 2 54.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101780546..102016805, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101950201..102186460, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene proline rich 5 like Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene STARR-seq mESC enhancer starr_05238 Neighboring gene COMM domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101819193-101819405 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101831937-101832164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101833086-101833410 Neighboring gene predicted gene, 39888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101870916-101871189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101879569-101879838 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101916542-101916651 Neighboring gene predicted gene, 54138 Neighboring gene predicted gene 13919 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101957603-101957826 Neighboring gene STARR-seq mESC enhancer starr_05244 Neighboring gene STARR-seq mESC enhancer starr_05248 Neighboring gene STARR-seq mESC enhancer starr_05249 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene 13866 Neighboring gene predicted gene, 34268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Ma H, et al. Nature, 2020 Dec. PMID 33208938, Free PMC Article
    2. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. Ranganathan S, et al. J Neurosci, 2011 Jul 27. PMID 21795536, Free PMC Article
    3. Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. Noyes NC, et al. Biochemistry, 2016 Mar 1. PMID 26854353
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.
      Title: Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.
    2. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.
      Title: LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low-density lipoprotein receptor class A domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290784.1 → NP_001277713.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_001277713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      AK032208, BB349367, BX322585, BX571894
      UniProtKB/TrEMBL
      B7ZND2
      Conserved Domains (1) summary
      cd00112
      Location:32 → 64
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. NM_178886.3 → NP_849217.2  low-density lipoprotein receptor class A domain-containing protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_849217.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK032208, BB349367, BX322585, BX571894
      Consensus CDS
      CCDS38187.1
      UniProtKB/Swiss-Prot
      A2AR95, A2AR96, Q8CCS0, Q8CDR7
      UniProtKB/TrEMBL
      B2RR20
      Related
      ENSMUSP00000054134.6, ENSMUST00000058790.12
      Conserved Domains (1) summary
      cd00112
      Location:32 → 64
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      101780546..102016805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161917.1 → XP_036017810.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      cd00112
      Location:39 → 74
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. XM_006499481.4 → XP_006499544.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AR95
      Related
      ENSMUSP00000106853.2, ENSMUST00000111222.2
      Conserved Domains (1) summary
      cd00112
      Location:39 → 74
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    3. XM_006499482.1 → XP_006499545.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform X3

      Conserved Domains (2) summary
      cd00112
      Location:36 → 71
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:2 → 29
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AR95.1 GenPept UniProtKB/Swiss-Prot:A2AR95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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