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    Cdk8 Cyclin-dependent kinase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39157, updated on 10-May-2024

    Summary

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    Official Symbol
    Cdk8provided by FlyBase
    Official Full Name
    Cyclin-dependent kinase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0015618
    Locus tag
    Dmel_CG10572
    See related
    AllianceGenome:FB:FBgn0015618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdk8; CDK8; CG10572; dCdk8; DmCdk8; Dmel\CG10572; dTRAP56; p58
    Summary
    Enables kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; imaginal disc-derived leg segmentation; and sensory organ development. Located in nucleus. Part of mediator complex. Is expressed in central brain primordium; organism; and ventral nerve cord primordium. Used to study developmental and epileptic encephalopathy 87. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to several human genes including CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cdk8 in Genome Data Viewer
    Location:
    67C10-67C10; 3-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9837080..9838670, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9830180..9831770, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 5 Neighboring gene Inhibitor-2 Neighboring gene Ras GTPase activating protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site. Xu W, et al. Int J Mol Sci, 2020 Oct 12. PMID 33053834, Free PMC Article
    2. De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. Chung HL, et al. Am J Hum Genet, 2020 May 7. PMID 32330417, Free PMC Article
    3. CDK8 mediates the dietary effects on developmental transition in Drosophila. Gao X, et al. Dev Biol, 2018 Dec 15. PMID 30352217, Free PMC Article
    4. Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Wang W, et al. Genetics, 2008 Aug. PMID 18689877, Free PMC Article
    5. A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila. Gobert V, et al. Mol Cell Biol, 2010 Jun. PMID 20368357, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. During the larval-pupal transition, the levels of CDK8 protein positively correlate with EcR and USP levels.
      Title: CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
    2. observed biochemical association between Integrator proteins and cyclin C/Cdk8, and that overexpression of a kinase-dead Cdk8 causes snRNA misprocessing
      Title: An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
    3. Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture.
      Title: A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex comb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CKM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cyclin-dependent kinase 8
    Names
    CG10572-PA
    Cdk8-PA
    NP_536735.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9837080..9838670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080487.4 → NP_536735.2  Cyclin-dependent kinase 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536735.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91642, Q8MS41, Q9VT57
      UniProtKB/TrEMBL
      C9QP81
      Related
      FBpp0076098
      Conserved Domains (2) summary
      smart00220
      Location:22 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07842
      Location:19 → 335
      STKc_CDK8_like; Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT57.2 Q9VT57

    Gene LinkOut

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