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    Lsm11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36013, updated on 10-May-2024

    Summary

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    Official Symbol
    Lsm11provided by FlyBase
    Primary source
    FLYBASE:FBgn0033450
    Locus tag
    Dmel_CG12924
    See related
    AllianceGenome:FB:FBgn0033450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12924; dLsm11; DLsm11; Dmel\CG12924; LSM11
    Summary
    Predicted to enable U7 snRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in histone locus body. Part of cytoplasmic U snRNP body and histone pre-mRNA 3'end processing complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human LSM11 (LSM11, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Lsm11 in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9838434..9839500, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5725939..5727005, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene dilatory Neighboring gene hebe Neighboring gene uncharacterized protein Neighboring gene Mitochondrial amidoxime reducing component Neighboring gene Vesicle-associated membrane protein 7 Neighboring gene sting Neighboring gene Origin recognition complex subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. Godfrey AC, et al. RNA, 2009 Sep. PMID 19620235, Free PMC Article
    2. Superresolution light microscopy of the Drosophila histone locus body reveals a core-shell organization associated with expression of replication-dependent histone genes. Kemp JP Jr, et al. Mol Biol Cell, 2021 Apr 19. PMID 33788585, Free PMC Article
    3. Drosophila histone locus body assembly and function involves multiple interactions. Koreski KP, et al. Mol Biol Cell, 2020 Jul 1. PMID 32401666, Free PMC Article
    4. Myc localizes to histone locus bodies during replication in Drosophila. Daneshvar K, et al. PLoS One, 2011. PMID 21886841, Free PMC Article
    5. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. Burch BD, et al. RNA, 2011 Jun. PMID 21525146, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila
      Title: Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila.
    2. The different terminal developmental phenotypes result from the participation of Lsm10 and Lsm11 in an essential function that is distinct from histone pre-mRNA processing and that is independent of U7 snRNA.
      Title: The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U7 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U7 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    part_of U7 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic U snRNP body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone pre-mRNA 3'end processing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lsm11
    Names
    CG12924-PA
    Lsm11-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9838434..9839500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136678.3 → NP_610522.1  Lsm11 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610522.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z802, Q8MRZ3
      Related
      FBpp0087569
      Conserved Domains (2) summary
      cd01739
      Location:158 → 204
      LSm11_M; Like-Sm protein 11, middle domain
      cl00259
      Location:166 → 252
      Sm_like; Sm and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z802 A1Z802
    Q8MRZ3 Q8MRZ3

    Gene LinkOut

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