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    Angel1 angel homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362765, updated on 2-May-2024

    Summary

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    Official Symbol
    Angel1provided by RGD
    Official Full Name
    angel homolog 1provided by RGD
    Primary source
    RGD:1306238
    See related
    Ensembl:ENSRNOG00000010567 AllianceGenome:RGD:1306238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306238
    Summary
    Predicted to enable 3'-5'-exoribonuclease activity; eukaryotic initiation factor 4E binding activity; and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Orthologous to human ANGEL1 (angel homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 68.0), Brain (RPKM 32.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Angel1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112080074..112117178, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106349125..106386202, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (110644327..110681397, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2, pseudogene 1 Neighboring gene vasohibin 1 Neighboring gene leucine rich repeat containing 74A Neighboring gene uncharacterized LOC108351370

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Gosselin P, et al. Nucleic Acids Res, 2013 Sep. PMID 23814182, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic initiation factor 4E binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein angel homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108717.1 → NP_001102187.1  protein angel homolog 1

      See identical proteins and their annotated locations for NP_001102187.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/Swiss-Prot
      B2RYM0
      UniProtKB/TrEMBL
      A6JE63
      Related
      ENSRNOP00000014635.3, ENSRNOT00000014635.5
      Conserved Domains (1) summary
      cl00490
      Location:245 → 660
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112080074..112117178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594229.3 → XP_017449718.1  protein angel homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3W9
      Related
      ENSRNOP00000072809.2
      Conserved Domains (1) summary
      cl00490
      Location:268 → 683
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. XM_006240392.5 → XP_006240454.1  protein angel homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3W9
      Conserved Domains (1) summary
      cl00490
      Location:258 → 673
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. XM_039112514.2 → XP_038968442.1  protein angel homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3W9
      Conserved Domains (1) summary
      cl00490
      Location:268 → 683
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. XM_039112516.2 → XP_038968444.1  protein angel homolog 1 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:258 → 673
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. XM_039112517.2 → XP_038968445.1  protein angel homolog 1 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:199 → 614
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    6. XM_008764815.4 → XP_008763037.1  protein angel homolog 1 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:199 → 614
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RYM0.2 GenPept UniProtKB/Swiss-Prot:B2RYM0

    Gene LinkOut

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