Slpi secretory leukocyte peptidase inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slpiprovided by RGD
Official Full Name: secretory leukocyte peptidase inhibitorprovided by RGD
Primary source: RGD:621768
See related: Ensembl:ENSRNOG00000046699 AllianceGenome:RGD:621768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity; nucleic acid binding activity; and serine-type endopeptidase inhibitor activity. Involved in negative regulation of inflammatory response. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular space. Biomarker of chronic obstructive pulmonary disease; endophthalmitis; middle cerebral artery infarction; myocardial infarction; and polycystic ovary syndrome. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1544.1), Thymus (RPKM 672.9) and 2 other tissues See more
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Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173501573..173503822, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153082208..153084457, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160799979..160802228, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLPI in periodontal Ligament is not sleepy during biophysical force-induced tooth movement.
Title: SLPI in periodontal Ligament is not sleepy during biophysical force-induced tooth movement.
SLPI can overcome inhibition by central nervous system myelin and significantly enhance regeneration of transected retinal ganglion cell axons in rats.
Title: Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-β signaling protein Smad2.
The expression of SLPI was decreased but the expression of TGF-beta(1) was increased significantly in the bronchial and lung tissues of rats with COPD. Erythromycin reduced TGF levels and raised SLPI levels.
Title: [The effect of erythromycin on transforming growth factor-β(1) and secretory leukocyte proteinase inhibitor in a rat model of chronic obstructive pulmonary disease].
increased SLPI in PCOS skin wounds may help prevent an excessive inflammatory response and aberrant collagen deposition but not are sufficient to accelerate PCOS skin wound healing.
Title: Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds.
The expression of SLPI in the COPD rat models significantly decreased, which may be caused by the increased expression of TGF-beta(1).
Title: [Expression of secretory leukocyte proteinase inhibitor in the bronchi and lung tissues of chronic obstructive pulmonary disease rat models and the regulatory mechanism by transforming growth factor beta(1)].
Decreased expression of SLPI in the chronic obstructive pulmonary disease rat model may be mainly caused by the increased expression of TGFbeta(1), and this process is probably related to the activation of Smads signal pathway.
Title: Downregulation of secretory leukocyte proteinase inhibitor in chronic obstructive lung disease: the role of TGF-beta/Smads signaling pathways.
SLPI is expressed in the inflamed cornea, vitreous, and retina tissues of rat eyes with S. aureus endophthalmitis, suggesting that SLPI has an active role in the innate immunity of the eye
Title: Secretory leukocyte protease inhibitor is an inducible antimicrobial peptide expressed in Staphylococcus aureus endophthalmitis.
REVIEW: Endogenous generation of IL- 10 and IL- 13 as well as secretory leukocyte protease inhibitor (SLPI), significantly regulates the inflammatory response
Title: Endogenous regulation of the acute inflammatory response.
SLPI inhibition of NF-kappaB activation is mediated, in part, by competitive binding (blocking p65 binding) to the NF-kappaB consensus-binding site.
Title: Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding.
plays an important role in controlling excessive proteolysis and inflammation during a critical phase of early pregnancy.
Title: Estrogen induces expression of secretory leukocyte protease inhibitor in rat uterus.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretory leukocyte peptidase inhibitor

Names: secretory leukocyte protease inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053372.2 → NP_445824.2 secretory leukocyte peptidase inhibitor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JX77, M0RCZ7, Q9R0Z8, Q9WUQ4

Related

ENSRNOP00000070977.2, ENSRNOT00000078398.2

Conserved Domains (2) summary

smart00217
Location:86 → 131

WAP; Four-disulfide core domains

pfam00095
Location:32 → 76

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'