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    Agpat3 1-Acylglycerol-3-phosphate O-acyltransferase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39820, updated on 10-May-2024

    Summary

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    Official Symbol
    Agpat3provided by FlyBase
    Official Full Name
    1-Acylglycerol-3-phosphate O-acyltransferase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036623
    Locus tag
    Dmel_CG4729
    See related
    AllianceGenome:FB:FBgn0036623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AGPAT; AGPAT-3; AGPAT3; CG4729; DmAGPAT3-5; Dmel\CG4729
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Located in endomembrane system. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic/larval midgut; endoderm; and germ layer derivative. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Agpat3 in Genome Data Viewer
    Location:
    72E4-72E4; 3-44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16381772..16385957, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16374872..16379057, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene roquin Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene RING-associated factor 2 Neighboring gene uncharacterized protein Neighboring gene Gag-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Lipin interacts with insulin and TOR signaling pathways in the control of growth and lipid metabolism. Schmitt S, et al. J Cell Sci, 2015 Dec 1. PMID 26490996
    2. Coordinated control of adiposity and growth by anti-anabolic kinase ERK7. Hasygar K, et al. EMBO Rep, 2021 Feb 3. PMID 33369866, Free PMC Article
    3. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Olarte MJ, et al. Dev Cell, 2020 Aug 24. PMID 32730754, Free PMC Article
    4. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
    5. MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. Gan Z, et al. BMC Bioinformatics, 2014 Mar 12. PMID 24621103, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1-Acylglycerol-3-phosphate O-acyltransferase 3
    Names
    Agpat3-PA
    Agpat3-PB
    Agpat3-PC
    Agpat3-PD
    Agpat3-PE
    CG4729-PA
    CG4729-PB
    CG4729-PC
    CG4729-PD
    CG4729-PE
    NP_001246793.1
    NP_648888.1
    NP_730160.1
    NP_730161.1
    NP_730162.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16381772..16385957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140631.2 → NP_648888.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV50, Q9VV51
      Related
      FBpp0075175
      Conserved Domains (3) summary
      cd07990
      Location:64 → 260
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:12 → 376
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:247 → 325
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001259864.1 → NP_001246793.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEK7
      Conserved Domains (3) summary
      cd07990
      Location:75 → 271
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:23 → 387
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:258 → 336
      Acyltransf_C; Acyltransferase C-terminus

    3. NM_168662.2 → NP_730161.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV50, Q9VV51
      Related
      FBpp0075176
      Conserved Domains (3) summary
      cd07990
      Location:64 → 260
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:12 → 376
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:247 → 325
      Acyltransf_C; Acyltransferase C-terminus

    4. NM_168661.2 → NP_730160.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV50, Q9VV51
      Related
      FBpp0075177
      Conserved Domains (3) summary
      cd07990
      Location:64 → 260
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:12 → 376
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:247 → 325
      Acyltransf_C; Acyltransferase C-terminus

    5. NM_168663.2 → NP_730162.1  1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961F9
      Related
      FBpp0075178
      Conserved Domains (1) summary
      pfam16076
      Location:4 → 82
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5AEK7 D5AEK7
    Q961F9 Q961F9
    Q9VV51 Q9VV51

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