Rpt4 Regulatory particle triple-A ATPase 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpt4provided by FlyBase
Official Full Name: Regulatory particle triple-A ATPase 4provided by FlyBase
Primary source: FLYBASE:FBgn0028685
Locus tag: Dmel_CG3455
See related: AllianceGenome:FB:FBgn0028685
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3455; Dmel\CG3455; Dmp42D; Dm_Rpt4a; Dm_Rpt4b; l(1)G0114; l(1)G0227; l(1)G0345; p42D; S10b
Summary: Enables RNA polymerase I transcription regulatory region sequence-specific DNA binding activity. Involved in ovarian follicle cell development; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of proteasome regulatory particle, base subcomplex. Is expressed in adult head and organism. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6289470..6291245, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6183503..6185278, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome-activating activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cytosolic proteasome complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_572308.3

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