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    Ssbp4 single stranded DNA binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 76900, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ssbp4provided by MGI
    Official Full Name
    single stranded DNA binding protein 4provided by MGI
    Primary source
    MGI:MGI:1924150
    See related
    Ensembl:ENSMUSG00000070003 AllianceGenome:MGI:1924150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ssdp4; Sspb4; 1210002E11Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in gonad; limb; retina; telencephalon; and trunk somite. Orthologous to human SSBP4 (single stranded DNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 126.2), ovary adult (RPKM 102.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ssbp4 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71050135..71061084, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70597485..70608387, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene elongation factor RNA polymerase II Neighboring gene STARR-positive B cell enhancer ABC_E1369 Neighboring gene myo-inositol 1-phosphate synthase A1 Neighboring gene STARR-positive B cell enhancer ABC_E3777 Neighboring gene STARR-positive B cell enhancer ABC_E3778 Neighboring gene STARR-positive B cell enhancer ABC_E3779 Neighboring gene leucine rich repeat containing 25 Neighboring gene STARR-positive B cell enhancer ABC_E6645 Neighboring gene STARR-seq mESC enhancer starr_21778 Neighboring gene growth differentiation factor 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Mozhui K, et al. Behav Genet, 2007 Jan. PMID 17131200
    2. Single-stranded DNA binding proteins are required for LIM complexes to induce transcriptionally active chromatin and specify spinal neuronal identities. Lee B, et al. Development, 2016 May 15. PMID 26965372, Free PMC Article
    3. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
    4. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    single-stranded DNA-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372468.1 → NP_001359397.1  single-stranded DNA-binding protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 366
      SSDP; Single-stranded DNA binding protein, SSDP

    2. NM_001372469.1 → NP_001359398.1  single-stranded DNA-binding protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 346
      SSDP; Single-stranded DNA binding protein, SSDP

    3. NM_001372470.1 → NP_001359399.1  single-stranded DNA-binding protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 366
      SSDP; Single-stranded DNA binding protein, SSDP

    4. NM_001372471.1 → NP_001359400.1  single-stranded DNA-binding protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 338
      SSDP; Single-stranded DNA binding protein, SSDP

    5. NM_001372472.1 → NP_001359401.1  single-stranded DNA-binding protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 338
      SSDP; Single-stranded DNA binding protein, SSDP

    6. NM_001372473.1 → NP_001359402.1  single-stranded DNA-binding protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 356
      SSDP; Single-stranded DNA binding protein, SSDP

    7. NM_001372475.1 → NP_001359404.1  single-stranded DNA-binding protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 318
      SSDP; Single-stranded DNA binding protein, SSDP

    8. NM_001372476.1 → NP_001359405.1  single-stranded DNA-binding protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC157774
      UniProtKB/TrEMBL
      A0A1B0GRX5
      Related
      ENSMUSP00000147704.2, ENSMUST00000210369.2
      Conserved Domains (1) summary
      pfam04503
      Location:1 → 237
      SSDP; Single-stranded DNA binding protein, SSDP

    9. NM_001372477.1 → NP_001359406.1  single-stranded DNA-binding protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Conserved Domains (1) summary
      pfam04503
      Location:1 → 237
      SSDP; Single-stranded DNA binding protein, SSDP

    10. NM_001372478.1 → NP_001359407.1  single-stranded DNA-binding protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Conserved Domains (1) summary
      pfam04503
      Location:1 → 237
      SSDP; Single-stranded DNA binding protein, SSDP

    11. NM_001372479.1 → NP_001359408.1  single-stranded DNA-binding protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Conserved Domains (1) summary
      pfam04503
      Location:1 → 237
      SSDP; Single-stranded DNA binding protein, SSDP

    12. NM_133772.3 → NP_598533.2  single-stranded DNA-binding protein 4 isoform 6

      See identical proteins and their annotated locations for NP_598533.2

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Consensus CDS
      CCDS22374.1
      UniProtKB/TrEMBL
      Q3U4B1, Q99LZ8
      Related
      ENSMUSP00000059039.10, ENSMUST00000049908.11
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 338
      SSDP; Single-stranded DNA binding protein, SSDP

    RNA

    1. NR_164176.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Related
      ENSMUST00000211134.2

    2. NR_164177.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157774

    3. NR_164178.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157774

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71050135..71061084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242338.4 → XP_011240640.1  single-stranded DNA-binding protein 4 isoform X6

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 346
      SSDP; Single-stranded DNA binding protein, SSDP

    2. XM_036154374.1 → XP_036010267.1  single-stranded DNA-binding protein 4 isoform X5

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 356
      SSDP; Single-stranded DNA binding protein, SSDP

    3. XM_011242337.4 → XP_011240639.1  single-stranded DNA-binding protein 4 isoform X4

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 384
      SSDP; Single-stranded DNA binding protein, SSDP

    4. XM_006509784.5 → XP_006509847.1  single-stranded DNA-binding protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006509847.1

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 384
      SSDP; Single-stranded DNA binding protein, SSDP

    5. XM_036154375.1 → XP_036010268.1  single-stranded DNA-binding protein 4 isoform X7

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 318
      SSDP; Single-stranded DNA binding protein, SSDP

    6. XM_030243848.2 → XP_030099708.1  single-stranded DNA-binding protein 4 isoform X7

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 318
      SSDP; Single-stranded DNA binding protein, SSDP

    7. XM_011242336.4 → XP_011240638.1  single-stranded DNA-binding protein 4 isoform X3

      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 364
      SSDP; Single-stranded DNA binding protein, SSDP

    8. XM_006509790.5 → XP_006509853.1  single-stranded DNA-binding protein 4 isoform X5

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 356
      SSDP; Single-stranded DNA binding protein, SSDP

    9. XM_036154372.1 → XP_036010265.1  single-stranded DNA-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 384
      SSDP; Single-stranded DNA binding protein, SSDP

    10. XM_036154376.1 → XP_036010269.1  single-stranded DNA-binding protein 4 isoform X8

      Conserved Domains (1) summary
      pfam04503
      Location:45 → 290
      SSDP; Single-stranded DNA binding protein, SSDP

    11. XM_036154373.1 → XP_036010266.1  single-stranded DNA-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      Q99LZ8
      Conserved Domains (2) summary
      smart00667
      Location:17 → 43
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:81 → 366
      SSDP; Single-stranded DNA binding protein, SSDP
    Nucleotide Protein Strain
    Heading Accession and Version

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