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    Sesn1 sestrin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294518, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Sesn1provided by RGD
    Official Full Name
    sestrin 1provided by RGD
    Primary source
    RGD:1307517
    See related
    Ensembl:ENSRNOG00000000302 AllianceGenome:RGD:1307517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to leucine; cellular response to starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 161.7), Muscle (RPKM 122.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sesn1 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46876918..46970010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45294876..45387698)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46667116..46758306)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 162 Neighboring gene uncharacterized LOC120098881 Neighboring gene centrosomal protein 57-like 1 Neighboring gene armadillo repeat containing 2 Neighboring gene uncharacterized LOC103694446

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The critical role of Sestrin 1 in regulating the proliferation of cardiac fibroblasts. Sun G, et al. Arch Biochem Biophys, 2014 Jan 15. PMID 24315959
    2. Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy. Xu X, et al. Aging (Albany NY), 2021 Apr 22. PMID 33883304, Free PMC Article
    3. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. Velasco-Miguel S, et al. Oncogene, 1999 Jan 7. PMID 9926927
    4. Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. Xu D, et al. Am J Physiol Endocrinol Metab, 2019 May 1. PMID 30835510, Free PMC Article
    5. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Budanov AV, et al. Science, 2004 Apr 23. PMID 15105503

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy.
      Title: Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy.
    2. In skeletal muscle Sestrin1 expression is higher than Sestrin3, whereas Sestrin2 expression is markedly lower. Sestrin1 has the highest affinity for leucine and Sestrin3 has the lowest affinity. Overall, the results presented herein are consistent with a model in which leucine-induced activation of mTORC1 in skeletal muscle in vivo occurs primarily through release of Sestrin1 from GATOR2.
      Title: Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
    3. Sestrin 1 plays an important role in the proliferation of cardiac fibroblasts
      Title: The critical role of Sestrin 1 in regulating the proliferation of cardiac fibroblasts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-leucine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-leucine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on peroxide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to L-leucine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leucine starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sestrin-1
    NP_001401866.1
    XP_006256622.1
    XP_063135144.1
    XP_063135145.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414937.1 → NP_001401866.1  sestrin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AEX8
      Related
      ENSRNOP00000090761.1, ENSRNOT00000116987.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      46876918..46970010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256560.4 → XP_006256622.1  sestrin-1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4P1, A6K6Z8, D3ZJU4
      Related
      ENSRNOP00000073119.1
      Conserved Domains (1) summary
      pfam04636
      Location:106 → 550
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_063279074.1 → XP_063135144.1  sestrin-1 isoform X1

    3. XM_063279075.1 → XP_063135145.1  sestrin-1 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106396.1: Suppressed sequence

      Description
      NM_001106396.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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