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    Acsl6 acyl-CoA synthetase long-chain family member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117243, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Acsl6provided by RGD
    Official Full Name
    acyl-CoA synthetase long-chain family member 6provided by RGD
    Primary source
    RGD:69403
    See related
    Ensembl:ENSRNOG00000026745 AllianceGenome:RGD:69403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Facl6; Lacsl
    Summary
    Enables arachidonate-CoA ligase activity and protein homodimerization activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and triglyceride biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 283.1), Muscle (RPKM 230.5) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acsl6 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38940668..38999515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38439914..38501182)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39654771..39717592)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 Neighboring gene interleukin 3 Neighboring gene uncharacterized LOC120095100 Neighboring gene uncharacterized LOC120095099 Neighboring gene meiotic kinetochore factor Neighboring gene U6 spliceosomal RNA Neighboring gene folliculin interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transient maintenance in bioreactor improves health of neuronal cells. Di Loreto S, et al. In Vitro Cell Dev Biol Anim, 2006 May-Jun. PMID 16848632
    2. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Van Horn CG, et al. Biochemistry, 2005 Feb 8. PMID 15683247
    3. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. Marszalek JR, et al. J Biol Chem, 2005 Mar 18. PMID 15655248
    4. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Dillon JS, et al. Diabetes, 2000 Dec. PMID 11118002
    5. Cloning and functional expression of a novel long-chain acyl-CoA synthetase expressed in brain. Fujino T, et al. J Biochem, 1992 Feb. PMID 1569043

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
      Title: Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
    2. ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation
      Title: Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.
    3. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
      Title: ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
    4. Acsl6 functions primarily in DHA metabolism, and its overexpression increases DHA and AA internalization primarily during the first 24 h of neuronal differentiation to stimulate phospholipid synthesis and enhance neurite outgrowth
      Title: Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism.
    5. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
      Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to gravity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 6
    Names
    LACS 6
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 6
    long-chain acyl-CoA synthetase 6
    long-chain-fatty-acid--CoA ligase, brain isozyme
    NP_570095.2
    XP_006246283.3
    XP_006246284.3
    XP_006246286.1
    XP_038941005.2
    XP_063124393.1
    XP_063124394.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130739.2 → NP_570095.2  long-chain-fatty-acid--CoA ligase 6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P33124, Q63835, Q6IU14
      UniProtKB/TrEMBL
      A0A0A6YYM0, A6HEH5
      Related
      ENSRNOP00000080278.1, ENSRNOT00000107770.1
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38940668..38999515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246224.5 → XP_006246286.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      See identical proteins and their annotated locations for XP_006246286.1

      UniProtKB/TrEMBL
      A0A8I5ZSH7
      Conserved Domains (2) summary
      PLN02736
      Location:79 → 694
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. XM_006246221.5 → XP_006246283.3  long-chain-fatty-acid--CoA ligase 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B3S2

    3. XM_006246222.5 → XP_006246284.3  long-chain-fatty-acid--CoA ligase 6 isoform X1

    4. XM_063268324.1 → XP_063124394.1  long-chain-fatty-acid--CoA ligase 6 isoform X6

    5. XM_039085077.2 → XP_038941005.2  long-chain-fatty-acid--CoA ligase 6 isoform X3

    6. XM_063268323.1 → XP_063124393.1  long-chain-fatty-acid--CoA ligase 6 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33124.1 GenPept UniProtKB/Swiss-Prot:P33124

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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