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    Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64562, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prkab2provided by RGD
    Official Full Name
    protein kinase AMP-activated non-catalytic subunit beta 2provided by RGD
    Primary source
    RGD:620905
    See related
    Ensembl:ENSRNOG00000018166 AllianceGenome:RGD:620905
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis; regulation of primary metabolic process; and signal transduction. Located in apical plasma membrane and cytoplasm. Part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 427.2), Heart (RPKM 86.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prkab2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187946008..187961615)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (185257218..185272846)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199831990..199847623)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 391 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene flavin containing dimethylaniline monoxygenase 5 Neighboring gene uncharacterized LOC102550575 Neighboring gene transfer RNA glutamine (anticodon CUG) 4 Neighboring gene phosphodiesterase 4D interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. When phosphorylated at Thr148, the β2-subunit of AMP-activated kinase does not associate with glycogen in skeletal muscle. Xu H, et al. Am J Physiol Cell Physiol, 2016 Jul 1. PMID 27099349
    2. AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis. Katwan OJ, et al. Biochem J, 2019 Jun 26. PMID 31189568, Free PMC Article
    3. Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro. Klaus A, et al. PLoS One, 2013. PMID 23741294, Free PMC Article
    4. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Woods A, et al. Curr Biol, 2003 Nov 11. PMID 14614828
    5. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. Chen Z, et al. FEBS Lett, 1999 Oct 29. PMID 10544261

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data indicate that increased expression of AMPKbeta2 is an important feature of efficient adipogenesis.
      Title: AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis.
    2. In rat skeletal muscle, beta2-AMPK is not associated with glycogen and that activation of AMPK by muscle contraction does not dephosphorylate beta2-AMPK.
      Title: When phosphorylated at Thr148, the β2-subunit of AMP-activated kinase does not associate with glycogen in skeletal muscle.
    3. Results suggest that p38 MAPK is not a downstream component of AMPK-mediated signaling in skeletal muscle.
      Title: Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC93432

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to AMP-activated protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cAMP-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'-AMP-activated protein kinase subunit beta-2
    Names
    AMP-activated protein kinase beta-2 regulatory subunit
    AMPK beta-2 chain
    AMPK subunit beta-2
    protein kinase, AMP-activated, beta 2 non-catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022627.2 → NP_072149.1  5'-AMP-activated protein kinase subunit beta-2

      See identical proteins and their annotated locations for NP_072149.1

      Status: PROVISIONAL

      Source sequence(s)
      AF182717
      UniProtKB/Swiss-Prot
      Q9QZH4
      Related
      ENSRNOP00000086904.1, ENSRNOT00000099010.1
      Conserved Domains (2) summary
      smart01010
      Location:182 → 271
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:77 → 160
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187946008..187961615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103079.2 → XP_038959007.1  5'-AMP-activated protein kinase subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLG3
      Related
      ENSRNOP00000078691.1
      Conserved Domains (2) summary
      smart01010
      Location:101 → 190
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:24 → 79
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    2. XM_006233011.4 → XP_006233073.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006233073.1

      UniProtKB/TrEMBL
      A0A0G2JVK3, A6K3B7
      Conserved Domains (2) summary
      smart01010
      Location:182 → 271
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:76 → 160
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    3. XM_006233012.3 → XP_006233074.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006233074.1

      UniProtKB/TrEMBL
      A0A0G2JVK3, A6K3B7
      Conserved Domains (2) summary
      smart01010
      Location:182 → 271
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:76 → 160
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    4. XM_039103080.1 → XP_038959008.1  5'-AMP-activated protein kinase subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLG3
      Conserved Domains (2) summary
      smart01010
      Location:101 → 190
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:24 → 79
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    5. XM_039103078.2 → XP_038959006.1  5'-AMP-activated protein kinase subunit beta-2 isoform X2

      Conserved Domains (2) summary
      smart01010
      Location:138 → 227
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:32 → 116
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    RNA

    1. XR_005500366.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZH4.1 GenPept UniProtKB/Swiss-Prot:Q9QZH4

    Gene LinkOut

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