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    Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170905, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lfngprovided by RGD
    Official Full Name
    LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by RGD
    Primary source
    RGD:620587
    See related
    Ensembl:ENSRNOG00000001250 AllianceGenome:RGD:620587
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Predicted to act upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be integral component of Golgi membrane. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 148.2), Lung (RPKM 128.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lfng in Genome Data Viewer
    Location:
    12q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19144474..19152951, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14030551..14038996, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16117767..16126211, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3 Neighboring gene galectin-related inter-fiber protein Neighboring gene carbohydrate sulfotransferase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine. Dunwoodie SL. Biochim Biophys Acta, 2009 Feb. PMID 19061953
    2. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Sparrow DB, et al. Am J Hum Genet, 2006 Jan. PMID 16385447, Free PMC Article
    3. Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling. Okubo Y, et al. Nat Commun, 2012. PMID 23072809
    4. Fringe is a glycosyltransferase that modifies Notch. Moloney DJ, et al. Nature, 2000 Jul 27. PMID 10935626
    5. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Tan JB, et al. Immunity, 2009 Feb 20. PMID 19217325

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.
      Title: Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in compartment pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within compartment pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in marginal zone B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in marginal zone B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in marginal zone B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of Notch signaling pathway involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway involved in somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway involved in somitogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somitogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Names
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    lunatic fringe gene homolog
    NP_596884.1
    XP_017453739.1
    XP_063127094.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133393.2 → NP_596884.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor

      See identical proteins and their annotated locations for NP_596884.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070933
      UniProtKB/Swiss-Prot
      Q924T4
      UniProtKB/TrEMBL
      A0A8L2UHG7, A6K1R9
      Related
      ENSRNOP00000086737.1, ENSRNOT00000101623.1
      Conserved Domains (1) summary
      pfam02434
      Location:109 → 357
      Fringe; Fringe-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19144474..19152951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598250.3 → XP_017453739.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1

    2. XM_063271024.1 → XP_063127094.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924T4.1 GenPept UniProtKB/Swiss-Prot:Q924T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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