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    Pls3 plastin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81748, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pls3provided by RGD
    Official Full Name
    plastin 3provided by RGD
    Primary source
    RGD:621409
    See related
    Ensembl:ENSRNOG00000027520 AllianceGenome:RGD:621409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be a structural constituent of presynaptic actin cytoskeleton. Involved in inner ear auditory receptor cell differentiation. Located in stereocilium. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human PLS3 (plastin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 442.8), Liver (RPKM 227.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pls3 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (116401247..116495898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (111589193..111683908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (119030311..119124268)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 9 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene uncharacterized LOC134484073 Neighboring gene uncharacterized LOC120099378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cells. Daudet N, et al. Cell Motil Cytoskeleton, 2002 Dec. PMID 12378542
    2. PLS3 mutations in X-linked osteoporosis with fractures. van Dijk FS, et al. N Engl J Med, 2013 Oct 17. PMID 24088043
    3. Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. Ackermann B, et al. Hum Mol Genet, 2013 Apr 1. PMID 23263861
    4. Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Chafel MM, et al. Dev Dyn, 1995 Jun. PMID 7655078
    5. Review series: The cell biology of hearing. Schwander M, et al. J Cell Biol, 2010 Jul 12. PMID 20624897, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of presynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner ear auditory receptor cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plastin-3
    Names
    T-plastin
    plastin 3 (T-isoform)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031084.1 → NP_112346.1  plastin-3

      See identical proteins and their annotated locations for NP_112346.1

      Status: VALIDATED

      Source sequence(s)
      BC092611, CB557206, CB798973
      UniProtKB/Swiss-Prot
      Q63598
      UniProtKB/TrEMBL
      A6KGB3
      Related
      ENSRNOP00000056912.4, ENSRNOT00000060168.3
      Conserved Domains (5) summary
      cd00051
      Location:16 → 82
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101 → 245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21328
      Location:254 → 375
      CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
      cd21331
      Location:377 → 510
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:519 → 630
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      116401247..116495898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257434.3 → XP_006257496.1  plastin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q63598
      Conserved Domains (5) summary
      cd00051
      Location:16 → 82
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101 → 245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21331
      Location:386 → 519
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:528 → 639
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
      cl00030
      Location:254 → 384
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_063280326.1 → XP_063136396.1  plastin-3 isoform X2

      UniProtKB/Swiss-Prot
      Q63598

    3. XM_063280325.1 → XP_063136395.1  plastin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q63598

    4. XM_017602163.3 → XP_017457652.1  plastin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q63598
      Conserved Domains (5) summary
      cd00051
      Location:16 → 82
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101 → 245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21331
      Location:386 → 519
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:528 → 639
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
      cl00030
      Location:254 → 384
      CH_SF; calponin homology (CH) domain superfamily

    5. XM_006257438.5 → XP_006257500.1  plastin-3 isoform X3

      See identical proteins and their annotated locations for XP_006257500.1

      UniProtKB/Swiss-Prot
      Q63598
      UniProtKB/TrEMBL
      A6KGB3
      Conserved Domains (5) summary
      cd00051
      Location:16 → 82
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101 → 245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21328
      Location:254 → 375
      CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
      cd21331
      Location:377 → 510
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:519 → 630
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3

    6. XM_017602164.3 → XP_017457653.1  plastin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q63598
      Conserved Domains (5) summary
      cd00051
      Location:16 → 82
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101 → 245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21331
      Location:386 → 519
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:528 → 639
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
      cl00030
      Location:254 → 384
      CH_SF; calponin homology (CH) domain superfamily

    7. XM_063280327.1 → XP_063136397.1  plastin-3 isoform X3

      UniProtKB/Swiss-Prot
      Q63598
      UniProtKB/TrEMBL
      A6KGB3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63598.2 GenPept UniProtKB/Swiss-Prot:Q63598

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