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    Med25 mediator complex subunit 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292889, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Med25provided by RGD
    Official Full Name
    mediator complex subunit 25provided by RGD
    Primary source
    RGD:1305137
    See related
    Ensembl:ENSRNOG00000020363 AllianceGenome:RGD:1305137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305137
    Summary
    Predicted to enable retinoid X receptor binding activity and transcription coactivator binding activity. Predicted to be involved in several processes, including positive regulation of chromatin binding activity; positive regulation of mediator complex assembly; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of mediator complex and transcription regulator complex. Orthologous to human MED25 (mediator complex subunit 25). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 63.2), Adrenal (RPKM 55.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med25 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104496447..104513061, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95359961..95375827, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100872240..100887864, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase 3'-phosphatase Neighboring gene PTOV1, extended AT-hook containing adaptor protein Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene testis-specific serine kinase substrate

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Leal A, et al. Neurogenetics, 2009 Oct. PMID 19290556, Free PMC Article
    2. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nakamura Y, et al. Nat Commun, 2011. PMID 21427722, Free PMC Article
    3. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. Lee HK, et al. EMBO J, 2007 Aug 8. PMID 17641689, Free PMC Article
    4. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Med25 is coordinately expressed with Pmp22 gene dosage and expression in transgenic mice and rats, and suggest a potential role of this protein in the molecular etiology of Charcot-Marie-Tooth disease.
      Title: Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mediator complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 25
    Names
    mediator of RNA polymerase II transcription, subunit 25 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170426.2 → NP_001163897.1  mediator of RNA polymerase II transcription subunit 25 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAU0
      Related
      ENSRNOP00000094991.1, ENSRNOT00000117952.1
      Conserved Domains (4) summary
      pfam11232
      Location:401 → 546
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228 → 384
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:664 → 746
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:13 → 225
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    2. NM_001415793.1 → NP_001402722.1  mediator of RNA polymerase II transcription subunit 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAU0

    3. NM_001415794.1 → NP_001402723.1  mediator of RNA polymerase II transcription subunit 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAU0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104496447..104513061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284057.1 → XP_063140127.1  mediator of RNA polymerase II transcription subunit 25 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B1T5

    2. XM_006229010.5 → XP_006229072.3  mediator of RNA polymerase II transcription subunit 25 isoform X3

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (6) summary
      pfam09770
      Location:612 → 743
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:462 → 571
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289 → 445
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:683 → 739
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73 → 287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
      pfam18658
      Location:754 → 812
      zf-C2H2_12; Zinc-finger C2H2-type

    3. XM_006229007.5 → XP_006229069.3  mediator of RNA polymerase II transcription subunit 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJG1, A0A8I6B1T5
      Related
      ENSRNOP00000093019.1
      Conserved Domains (6) summary
      pfam09770
      Location:648 → 779
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:462 → 607
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289 → 445
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:719 → 775
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73 → 287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
      pfam18658
      Location:790 → 848
      zf-C2H2_12; Zinc-finger C2H2-type

    4. XM_006229013.3 → XP_006229075.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

      UniProtKB/TrEMBL
      D3ZJW8
      Conserved Domains (6) summary
      pfam09770
      Location:484 → 615
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298 → 443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125 → 281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555 → 611
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam18658
      Location:626 → 684
      zf-C2H2_12; Zinc-finger C2H2-type
      cl00057
      Location:1 → 123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. XM_063284073.1 → XP_063140143.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

      UniProtKB/TrEMBL
      D3ZJW8

    6. XM_039104904.2 → XP_038960832.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

      UniProtKB/TrEMBL
      D3ZJW8
      Conserved Domains (6) summary
      pfam09770
      Location:484 → 615
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298 → 443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125 → 281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555 → 611
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam18658
      Location:626 → 684
      zf-C2H2_12; Zinc-finger C2H2-type
      cl00057
      Location:1 → 123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    7. XM_063284064.1 → XP_063140134.1  mediator of RNA polymerase II transcription subunit 25 isoform X7

      UniProtKB/TrEMBL
      A0A8I6B1T5

    8. XM_039104896.2 → XP_038960824.1  mediator of RNA polymerase II transcription subunit 25 isoform X6

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (4) summary
      pfam11232
      Location:461 → 606
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289 → 444
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:694 → 782
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73 → 287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    9. XM_006229011.5 → XP_006229073.3  mediator of RNA polymerase II transcription subunit 25 isoform X4

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (4) summary
      pfam11232
      Location:461 → 606
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289 → 444
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:718 → 806
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73 → 287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    10. XM_063284065.1 → XP_063140135.1  mediator of RNA polymerase II transcription subunit 25 isoform X8

      UniProtKB/TrEMBL
      A0A8I6B1T5

    11. XM_006229012.5 → XP_006229074.3  mediator of RNA polymerase II transcription subunit 25 isoform X5

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (4) summary
      pfam11232
      Location:462 → 607
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289 → 445
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:695 → 783
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73 → 287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    12. XM_063284077.1 → XP_063140147.1  mediator of RNA polymerase II transcription subunit 25 isoform X10

    RNA

    1. XR_010064657.1 RNA Sequence

    2. XR_010064656.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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