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    Frrs1 ferric-chelate reductase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310810, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Frrs1provided by RGD
    Official Full Name
    ferric-chelate reductase 1provided by RGD
    Primary source
    RGD:1306883
    See related
    Ensembl:ENSRNOG00000016351 AllianceGenome:RGD:1306883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sdfr2
    Summary
    Predicted to enable oxidoreductase activity, acting on metal ions. Predicted to be involved in cellular iron ion homeostasis. Predicted to be integral component of membrane. Orthologous to human FRRS1 (ferric chelate reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 156.3), Spleen (RPKM 69.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frrs1 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207505786..207566376)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204820898..204881487)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (220415568..220469559)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100926 Neighboring gene amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Neighboring gene uncharacterized LOC102548573 Neighboring gene uncharacterized LOC102548639 Neighboring gene palmdelphin Neighboring gene phospholipid phosphatase related 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Vargas JD, et al. Biochim Biophys Acta, 2003 Sep 23. PMID 14499595
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on metal ions IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on metal ions ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferric-chelate reductase 1
    Names
    stromal cell derived factor receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398971.2 → NP_001385900.1  ferric-chelate reductase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AH47
      Related
      ENSRNOP00000094184.1, ENSRNOT00000103063.1
      Conserved Domains (3) summary
      cd08760
      Location:320 → 533
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:192 → 354
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:32 → 155
      Reeler; Reeler domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      207505786..207566376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103831.2 → XP_038959759.1  ferric-chelate reductase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH47
      Conserved Domains (3) summary
      cd08760
      Location:320 → 533
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:192 → 354
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:32 → 155
      Reeler; Reeler domain

    2. XM_039103832.2 → XP_038959760.1  ferric-chelate reductase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH47
      Related
      ENSRNOP00000089230.1
      Conserved Domains (3) summary
      cd08760
      Location:320 → 533
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:192 → 354
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:32 → 155
      Reeler; Reeler domain
    Nucleotide Protein Strain
    Heading Accession and Version

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