Gpat2 glycerol-3-phosphate acyltransferase 2, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpat2provided by RGD
Official Full Name: glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by RGD
Primary source: RGD:1304904
See related: Ensembl:ENSRNOG00000013906 AllianceGenome:RGD:1304904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304904
Summary: Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including glycerol-3-phosphate metabolic process; glycerolipid biosynthetic process; and piRNA biosynthetic process. Located in mitochondrial outer membrane. Orthologous to human GPAT2 (glycerol-3-phosphate acyltransferase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 38.4), Kidney (RPKM 9.8) and 8 other tissues See more
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Genomic context

Location:: 3q36

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (135099751..135110355)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114646446..114657051)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119949921..120003090)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPAT2 expression is linked to arachidonoyl-CoA incorporation into TAG in spermatogenic germ cells
Title: Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphate O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycerol-3-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycerol-3-phosphate acyltransferase 2, mitochondrial

Names: 1-acylglycerol-3-phosphate O-acyltransferase GPAT2

NP_001162001.1

EC 2.3.1.15

EC 2.3.1.51

XP_017447069.1

EC 2.3.1.15

EC 2.3.1.51

XP_038960496.1

EC 2.3.1.15

EC 2.3.1.51

XP_038960497.1

EC 2.3.1.15

EC 2.3.1.51

XP_063139400.1

EC 2.3.1.15

EC 2.3.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168529.1 → NP_001162001.1 glycerol-3-phosphate acyltransferase 2, mitochondrial

See identical proteins and their annotated locations for NP_001162001.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

D3ZI76

UniProtKB/TrEMBL

A0A8I5ZY97

Related

ENSRNOP00000018677.5, ENSRNOT00000018677.7

Conserved Domains (1) summary

cd07993
Location:176 → 387

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

135099751..135110355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591580.2 → XP_017447069.1 glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZY97

Conserved Domains (1) summary

cd07993
Location:176 → 387

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
XM_039104569.1 → XP_038960497.1 glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3

UniProtKB/Swiss-Prot

D3ZI76

UniProtKB/TrEMBL

A0A8I5ZY97

Conserved Domains (1) summary

cd07993
Location:176 → 387

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
XM_039104568.1 → XP_038960496.1 glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZY97

Conserved Domains (1) summary

cd07993
Location:176 → 387

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
XM_063283330.1 → XP_063139400.1 glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I5ZY97