Rab7b Rab7b, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab7bprovided by RGD
Official Full Name: Rab7b, member RAS oncogene familyprovided by RGD
Primary source: RGD:1562617
See related: Ensembl:ENSRNOG00000039754 AllianceGenome:RGD:1562617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562617
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including late endosome to Golgi transport; negative regulation of toll-like receptor signaling pathway; and regulation of gene expression. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in trans-Golgi network. Predicted to be active in late endosome; lysosome; and phagocytic vesicle. Orthologous to human RAB7B (RAB7B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 43.1), Spleen (RPKM 17.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45673396..45699798)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (43121168..43147581)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (48456143..48483714)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab7b was upregulated in the rat brain following the transient middle cerebral artery occlusion. Overexpression of Rab7b in the brain by DNA transfection reduced cerebral infarction.
Title: Rab7b Overexpression-Ameliorated Ischemic Brain Damage Following tMCAO Involves Suppression of TLR4 and NF-κB p65.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-7b

NP_001102798.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_008767713.2

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_008767714.2

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_017454394.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_063128624.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109328.2 → NP_001102798.1 ras-related protein Rab-7b

See identical proteins and their annotated locations for NP_001102798.1

Status: VALIDATED

Source sequence(s)

FM076322, JAXUCZ010000013

UniProtKB/TrEMBL

A6IC28, A6IC29, D4A7A8

Related

ENSRNOP00000009280.3, ENSRNOT00000009280.6

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

45673396..45699798

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598905.3 → XP_017454394.1 ras-related protein Rab-7b isoform X2

UniProtKB/TrEMBL

A0A8I6A7M1

Related

ENSRNOP00000088975.1
XM_063272554.1 → XP_063128624.1 ras-related protein Rab-7b isoform X2

UniProtKB/TrEMBL

A0A8I6A7M1
XM_008769491.4 → XP_008767713.2 ras-related protein Rab-7b isoform X1

UniProtKB/TrEMBL

A6IC28, A6IC29, D4A7A8

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
XM_008769492.4 → XP_008767714.2 ras-related protein Rab-7b isoform X1

UniProtKB/TrEMBL

A6IC28, A6IC29, D4A7A8

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)