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    Irf2 interferon regulatory factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290749, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Irf2provided by RGD
    Official Full Name
    interferon regulatory factor 2provided by RGD
    Primary source
    RGD:1304922
    See related
    Ensembl:ENSRNOG00000009824 AllianceGenome:RGD:1304922
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to virus; immune system process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human IRF2 (interferon regulatory factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 139.1), Thymus (RPKM 112.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Irf2 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52171855..52283620, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45439215..45550054, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48582354..48732129, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482380 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3, pseudogene 1 Neighboring gene uncharacterized LOC102552290 Neighboring gene uncharacterized LOC134482504 Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 3 Neighboring gene uncharacterized LOC120097385 Neighboring gene uncharacterized LOC134482506 Neighboring gene ribosomal protein L4, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. Aziz F, et al. Mol Biol Rep, 1998 Jan. PMID 9540062
    2. A diverse range of gene products are effectors of the type I interferon antiviral response. Schoggins JW, et al. Nature, 2011 Apr 28. PMID 21478870, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon regulatory factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047086.1 → NP_001040551.1  interferon regulatory factor 2

      See identical proteins and their annotated locations for NP_001040551.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ674266
      UniProtKB/TrEMBL
      A0A0G2K1F1, A0A9K3Y6S1, Q0PXQ8
      Related
      ENSRNOP00000071815.2, ENSRNOT00000083632.2
      Conserved Domains (1) summary
      pfam00605
      Location:7 → 112
      IRF; Interferon regulatory factor transcription factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      52171855..52283620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275233.1 → XP_063131303.1  interferon regulatory factor 2 isoform X1

    2. XM_039094379.2 → XP_038950307.1  interferon regulatory factor 2 isoform X3

      Conserved Domains (1) summary
      pfam00605
      Location:2 → 74
      IRF; Interferon regulatory factor transcription factor

    3. XM_006253139.5 → XP_006253201.1  interferon regulatory factor 2 isoform X2

      See identical proteins and their annotated locations for XP_006253201.1

      UniProtKB/TrEMBL
      A0A0G2K1F1, A0A9K3Y6S1, Q0PXQ8
      Conserved Domains (1) summary
      pfam00605
      Location:7 → 112
      IRF; Interferon regulatory factor transcription factor

    4. XM_063275234.1 → XP_063131304.1  interferon regulatory factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1F1, A0A9K3Y6S1, Q0PXQ8
    Nucleotide Protein Strain
    Heading Accession and Version

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