Il1rl2 interleukin 1 receptor-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il1rl2provided by RGD
Official Full Name: interleukin 1 receptor-like 2provided by RGD
Primary source: RGD:621782
See related: Ensembl:ENSRNOG00000014683 AllianceGenome:RGD:621782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1 receptor activity. Predicted to be involved in regulation of inflammatory response. Predicted to act upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Predicted to be integral component of membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 10.1), Lung (RPKM 9.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50087271..50134225)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (42591658..42639351)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47044870..47093679)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
Title: Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-1 receptor-like 2

Names: IL-1Rrp2; IL-36 receptor; IL1R-rp2; interleukin-1 receptor-related protein 2

NP_598259.2

EC 3.2.2.6

XP_017451748.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133575.2 → NP_598259.2 interleukin-1 receptor-like 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q62929

UniProtKB/TrEMBL

A6INN3, G3V7W4

Related

ENSRNOP00000019880.1, ENSRNOT00000019880.4

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:26 → 115

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

50087271..50134225

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596259.3 → XP_017451748.1 interleukin-1 receptor-like 2 isoform X1

UniProtKB/Swiss-Prot

Q62929

UniProtKB/TrEMBL

A6INN3, G3V7W4

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:26 → 115

Ig; Immunoglobulin domain