Bfsp1 beaded filament structural protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bfsp1provided by RGD
Official Full Name: beaded filament structural protein 1provided by RGD
Primary source: RGD:2205
See related: Ensembl:ENSRNOG00000005707 AllianceGenome:RGD:2205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CP94; CP95; CP97; 115-kDa
Summary: Predicted to be a structural constituent of eye lens. Predicted to be involved in intermediate filament organization and lens fiber cell development. Predicted to act upstream of or within cell maturation. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intermediate filament. Human ortholog(s) of this gene implicated in cataract 33. Orthologous to human BFSP1 (beaded filament structural protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 12.4), Heart (RPKM 11.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (151648588..151706153, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (131195087..131252668, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (137935345..137992652, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The degradation of filensin and phakinin in normal and cataractous rat lenses, was examined.
Title: The function of filensin and phakinin in lens transparency.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of eye lens	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables structural constituent of eye lens	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lens fiber cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in lens fiber cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens fiber cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: filensin

Names: CP97 115-kDa; beaded filament structural protein 1, filensin; lens fiber cell beaded-filament structural protein CP 94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031555.1 → NP_113743.1 filensin

Status: VALIDATED

Source sequence(s)

AB003104

UniProtKB/TrEMBL

F1M8F1

Related

ENSRNOP00000007727.4, ENSRNOT00000007727.6

Conserved Domains (1) summary

pfam00038
Location:37 → 312

Filament; Intermediate filament protein