Sesn2 sestrin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sesn2provided by RGD
Official Full Name: sestrin 2provided by RGD
Primary source: RGD:1566319
See related: Ensembl:ENSRNOG00000042785 AllianceGenome:RGD:1566319
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566319
Summary: Predicted to enable several functions, including GDP-dissociation inhibitor activity; leucine binding activity; and sulfiredoxin activity. Predicted to be involved in several processes, including cellular response to leucine; cellular response to starvation; and regulation of cellular macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including positive regulation of lipophagy; protein kinase B signaling; and regulation of cAMP-dependent protein kinase activity. Predicted to be located in cytoplasm. Predicted to be part of Atg1/ULK1 kinase complex; TORC2 complex; and nucleotide-activated protein kinase complex. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 154.9), Adrenal (RPKM 64.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (149986304..150005255, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (144702287..144721241, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (150684891..150703846, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The impact of sestrin2 on reactive oxygen species in diabetic retinopathy.
Title: The impact of sestrin2 on reactive oxygen species in diabetic retinopathy.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Title: Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
SESN2 protected against Dox-induced cardiotoxicity through improving mitochondria function and mitophagy. These results established SESN2 as a key player in mitochondrial function and provided a potential therapeutic approach to Dox-induced cardiomyopathy.
Title: SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function.
Sestrin 2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in rat retinal ganglion cells by downregulating Keap1 and reinforcing activation of Nrf2/antioxidant response element signaling.
Title: Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Sestrin2 overexpression activates the Nrf2/HO-1 pathway, leading to enhanced angiogenesis following cerebral ischemia.
Title: Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
In skeletal muscle Sestrin1 expression is higher than Sestrin3, whereas Sestrin2 expression is markedly lower. Sestrin1 has the highest affinity for leucine and Sestrin3 has the lowest affinity. Overall, the results presented herein are consistent with a model in which leucine-induced activation of mTORC1 in skeletal muscle in vivo occurs primarily through release of Sestrin1 from GATOR2.
Title: Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
Sesn2 promoted the transfer of nuclear factor E2 related factor 2 to the cytoplasm, it decreased the expressions of Nrf2 and its downstream proteins, sulfiredoxin1 and thioredoxin1 .
Title: Sestrin2 aggravates oxidative stress of neurons by decreasing the expression of Nrf2.
Sestrin 2 may attenuate the activation of Hepatic Stellate Cell and ameliorate liver fibrosis, most likely via upregulation of AMPK phosphorylation and suppression of the mTOR signaling pathway.
Title: Sestrin 2 Attenuates Rat Hepatic Stellate Cell (HSC) Activation and Liver Fibrosis via an mTOR/AMPK-Dependent Mechanism.
sesn2 has a role in lipopolysaccharide-induced oxidative stress in mice and in H9c2 cells
Title: Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism.
Sestrin 2 protected against cardiomyocyte hypertrophy induced by PE via inhibiting ERK1/2 signaling.
Title: Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1/2.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables L-leucine binding	ISO Inferred from Sequence Orthology more info
enables PH domain binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
NOT enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
NOT enables sulfiredoxin activity	ISO Inferred from Sequence Orthology more info
enables sulfiredoxin activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
NOT involved_in cellular oxidant detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial DNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lipophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sestrin-2

NP_001102828.1

EC 1.11.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.