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    Tsks testis-specific serine kinase substrate [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292890, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tsksprovided by RGD
    Official Full Name
    testis-specific serine kinase substrateprovided by RGD
    Primary source
    RGD:727784
    See related
    Ensembl:ENSRNOG00000020443 AllianceGenome:RGD:727784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stk22s1
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be located in cytoplasm. Predicted to be active in centriole. Orthologous to human TSKS (testis specific serine kinase substrate). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 700.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tsks in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104550790..104578147)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95414312..95441670)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100926569..100953950)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 25 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene protein arginine methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel family of serine/threonine kinases participating in spermiogenesis. Kueng P, et al. J Cell Biol, 1997 Dec 29. PMID 9412477, Free PMC Article
    2. TSKS concentrates in spermatid centrioles during flagellogenesis. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18495105, Free PMC Article
    3. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18533145, Free PMC Article
    4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine kinase substrate
    Names
    STK22 substrate 1
    serine/threonine kinase 22 substrate 1
    testis-specific kinase substrate

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199088.1 → NP_954519.1  testis-specific serine kinase substrate

      See identical proteins and their annotated locations for NP_954519.1

      Status: PROVISIONAL

      Source sequence(s)
      AY346104
      UniProtKB/Swiss-Prot
      P60531
      UniProtKB/TrEMBL
      A6JAU4
      Related
      ENSRNOP00000043218.4, ENSRNOT00000049584.4
      Conserved Domains (1) summary
      pfam15358
      Location:26 → 585
      TSKS; Testis-specific serine kinase substrate

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104550790..104578147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229016.5 → XP_006229078.1  testis-specific serine kinase substrate isoform X4

      Related
      ENSRNOP00000087658.1
      Conserved Domains (2) summary
      pfam15358
      Location:27 → 580
      TSKS; Testis-specific serine kinase substrate
      cl20817
      Location:178 → 228
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_063284148.1 → XP_063140218.1  testis-specific serine kinase substrate isoform X13

    3. XM_063284121.1 → XP_063140191.1  testis-specific serine kinase substrate isoform X7

    4. XM_063284124.1 → XP_063140194.1  testis-specific serine kinase substrate isoform X8

    5. XM_063284143.1 → XP_063140213.1  testis-specific serine kinase substrate isoform X12

    6. XM_063284153.1 → XP_063140223.1  testis-specific serine kinase substrate isoform X17

    7. XM_063284135.1 → XP_063140205.1  testis-specific serine kinase substrate isoform X10

    8. XM_063284150.1 → XP_063140220.1  testis-specific serine kinase substrate isoform X14

    9. XM_063284139.1 → XP_063140209.1  testis-specific serine kinase substrate isoform X11

      UniProtKB/TrEMBL
      A0A8I6A8E5

    10. XM_006229014.5 → XP_006229076.1  testis-specific serine kinase substrate isoform X1

      Conserved Domains (2) summary
      pfam15358
      Location:26 → 610
      TSKS; Testis-specific serine kinase substrate
      cl20817
      Location:208 → 258
      GBP_C; Guanylate-binding protein, C-terminal domain

    11. XM_006229018.5 → XP_006229080.1  testis-specific serine kinase substrate isoform X6

      Conserved Domains (2) summary
      pfam15358
      Location:26 → 492
      TSKS; Testis-specific serine kinase substrate
      cl20817
      Location:208 → 258
      GBP_C; Guanylate-binding protein, C-terminal domain

    12. XM_006229019.5 → XP_006229081.1  testis-specific serine kinase substrate isoform X15

      Conserved Domains (1) summary
      pfam15358
      Location:26 → 534
      TSKS; Testis-specific serine kinase substrate

    13. XM_006229015.4 → XP_006229077.1  testis-specific serine kinase substrate isoform X2

      Conserved Domains (2) summary
      pfam15358
      Location:26 → 601
      TSKS; Testis-specific serine kinase substrate
      cl23720
      Location:155 → 248
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    14. XM_063284130.1 → XP_063140200.1  testis-specific serine kinase substrate isoform X9

    15. XM_006229020.5 → XP_006229082.1  testis-specific serine kinase substrate isoform X16

      Conserved Domains (2) summary
      pfam15358
      Location:26 → 525
      TSKS; Testis-specific serine kinase substrate
      cl23720
      Location:155 → 248
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    16. XM_006229017.5 → XP_006229079.1  testis-specific serine kinase substrate isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHX2
      Conserved Domains (2) summary
      pfam15358
      Location:26 → 576
      TSKS; Testis-specific serine kinase substrate
      cl23720
      Location:155 → 248
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    17. XM_017588926.3 → XP_017444415.1  testis-specific serine kinase substrate isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60531.1 GenPept UniProtKB/Swiss-Prot:P60531

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