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    Tmem123 transmembrane protein 123 [ Mus musculus (house mouse) ]

    Gene ID: 71929, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tmem123provided by MGI
    Official Full Name
    transmembrane protein 123provided by MGI
    Primary source
    MGI:MGI:1919179
    See related
    Ensembl:ENSMUSG00000050912 AllianceGenome:MGI:1919179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310075C12Rik
    Summary
    Predicted to be involved in oncosis. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasmic vesicle. Orthologous to human TMEM123 (transmembrane protein 123). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 117.5), mammary gland adult (RPKM 52.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A1; 9 2.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7764078..7794334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7764077..7794333)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene chromobox 3, pseudogene 8 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2884 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7764868-7765169 Neighboring gene STARR-seq mESC enhancer starr_23223 Neighboring gene microRNA 5618 Neighboring gene baculoviral IAP repeat-containing 2 Neighboring gene STARR-seq mESC enhancer starr_23227 Neighboring gene baculoviral IAP repeat-containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7872853-7873154 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7873159-7873459

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123. Takekoshi T, et al. J Biol Chem, 2010 Oct 8. PMID 20685650, Free PMC Article
    2. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. Lü J, et al. J Biol Chem, 2005 Feb 11. PMID 15556938
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC102366

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    porimin
    Names
    pro-oncosis receptor inducing membrane injury

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133739.2 → NP_598500.1  porimin precursor

      See identical proteins and their annotated locations for NP_598500.1

      Status: VALIDATED

      Source sequence(s)
      AI448519, AK150361, AK162610, BY259389
      Consensus CDS
      CCDS22810.1
      UniProtKB/Swiss-Prot
      Q3T9F6, Q3TLL2, Q3U1R6, Q8CEX4, Q91Z22
      Related
      ENSMUSP00000051966.10, ENSMUST00000052865.16
      Conserved Domains (2) summary
      PRK13335
      Location:44 → 144
      PRK13335; superantigen-like protein SSL3; Reviewed
      pfam05283
      Location:95 → 175
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

    RNA

    1. NR_152989.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI448519, CT030639
      Related
      ENSMUST00000154371.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7764078..7794334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155305.1 → XP_036011198.1  porimin isoform X1

      Conserved Domains (2) summary
      PRK11907
      Location:11 → 107
      PRK11907; bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
      pfam05283
      Location:61 → 132
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Z22.1 GenPept UniProtKB/Swiss-Prot:Q91Z22

    Gene LinkOut

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