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    Cfap144 cilia and flagella associated protein 144 [ Mus musculus (house mouse) ]

    Gene ID: 75429, updated on 7-May-2024

    Summary

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    Official Symbol
    Cfap144provided by MGI
    Official Full Name
    cilia and flagella associated protein 144provided by MGI
    Primary source
    MGI:MGI:1922679
    See related
    Ensembl:ENSMUSG00000049154 AllianceGenome:MGI:1922679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Theg6; Fam183b; 3100002J23Rik
    Summary
    Located in centrosome; ciliary basal body; and ciliary base. Is expressed in several structures, including lung; nasal cavity respiratory epithelium; node; notochord; and reproductive system. Orthologous to several human genes including FAM183A (family with sequence similarity 183 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 7.7), lung adult (RPKM 0.8) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Cfap144 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58683628..58692786, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58783892..58802221, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 45 Neighboring gene olfactory receptor family 2 subfamily T member 44 Neighboring gene olfactory receptor family 5 subfamily AC member 20 Neighboring gene olfactory receptor family 5 subfamily AF member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Beckers A, et al. Sci Rep, 2018 Oct 2. PMID 30279523, Free PMC Article
    2. A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Dykes IM, et al. Sci Rep, 2018 Jul 11. PMID 29992973, Free PMC Article
    3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    4. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Surprisingly, mice homozygous for a null allele did not display any defects indicative of disrupted motile ciliary function.
      Title: The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143784

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM183B
    Names
    family with sequence similarity 183, member B
    testis highly expressed protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162878.3 → NP_001156350.2  protein FAM183B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL662903
      Consensus CDS
      CCDS48807.2
      Related
      ENSMUSP00000051960.5, ENSMUST00000060581.5
      Conserved Domains (1) summary
      pfam14886
      Location:19 → 101
      FAM183; FAM183A and FAM183B related

    2. NM_029283.3 → NP_083559.2  protein FAM183B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL662903
      Consensus CDS
      CCDS48808.2
      UniProtKB/Swiss-Prot
      Q3TZB7, Q5NC57, Q9CXW5
      Related
      ENSMUSP00000091708.6, ENSMUST00000094156.12
      Conserved Domains (1) summary
      pfam14886
      Location:19 → 121
      FAM183; FAM183A and FAM183B related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58683628..58692786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NC57.2 GenPept UniProtKB/Swiss-Prot:Q5NC57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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