Ecrg4 ECRG4 augurin precursor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ecrg4provided by MGI
Official Full Name: ECRG4 augurin precursorprovided by MGI
Primary source: MGI:MGI:1926146
See related: Ensembl:ENSMUSG00000026051 AllianceGenome:MGI:1926146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500015O10Rik
Summary: Predicted to enable neuropeptide hormone activity. Acts upstream of or within G1 to G0 transition; anaphase-promoting complex-dependent catabolic process; and cellular senescence. Located in extracellular space. Is expressed in several structures, including adrenal gland; central nervous system; heart; skeleton; and urinary system. Orthologous to human ECRG4 (ECRG4 augurin precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 16.3), ovary adult (RPKM 13.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 23.44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (43769762..43781724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (43730602..43742564)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury.
Title: ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury.
Ecrg4 has a role in aging of neural stem cells in a Foxg1-dependent manner
Title: Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner.
These data suggest that multiple scavenger receptors recognize Ecrg4(71-132) and transduce its signals, together with Toll-like receptors, in microglia.
Title: Ecrg4 peptide is the ligand of multiple scavenger receptors.
a wound termination factor during wound resolution after cutaneous injury
Title: The candidate tumor suppressor gene Ecrg4 as a wound terminating factor in cutaneous injury.
proteolytic cleavage by furin is a posttranslational requirement for proaugurin to suppress cell proliferation
Title: Processing of proaugurin is required to suppress proliferation of tumor cell lines.
identified esophageal cancer-related gene 4 (Ecrg4) as a senescence inducer with implications for the senescence-like state of postmitotic cells in the aging brain.
Title: Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
ECRG4 level in differentiated chondrocytes is decreased during hypertrophic maturation
Title: Esophageal cancer related gene 4 (ECRG4) is a marker of articular chondrocyte differentiation and cartilage destruction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G1 to G0 transition	IDA Inferred from Direct Assay more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular senescence	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin-releasing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vasopressin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in dense core granule	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: augurin

Names: esophageal cancer related gene 4 protein; esophageal cancer-related gene 4 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.