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    Elp6 elongator acetyltransferase complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 72341, updated on 12-May-2024

    Summary

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    Official Symbol
    Elp6provided by MGI
    Official Full Name
    elongator acetyltransferase complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1919349
    See related
    Ensembl:ENSMUSG00000054836 AllianceGenome:MGI:1919349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem103; 2610001P13Rik; 2610002I17Rik
    Summary
    Involved in positive regulation of cell migration. Predicted to be located in cytosol and nucleus. Predicted to be part of elongator holoenzyme complex. Orthologous to human ELP6 (elongator acetyltransferase complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E14 (RPKM 8.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F2; 9 59.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110133321..110151170)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110304398..110322102)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25258 Neighboring gene chondroitin sulfate proteoglycan 5 Neighboring gene predicted gene, 39429 Neighboring gene STARR-positive B cell enhancer ABC_E461 Neighboring gene microRNA 6236 Neighboring gene tropomyosin beta chain pseudogene Neighboring gene STARR-seq mESC enhancer starr_25259 Neighboring gene SREBF chaperone Neighboring gene STARR-seq mESC enhancer starr_25260 Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene STARR-positive B cell enhancer ABC_E6807

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Kojic M, et al. Nat Commun, 2018 Aug 10. PMID 30097576, Free PMC Article
    2. Cryo-EM structure of the fully assembled Elongator complex. Jaciuk M, et al. Nucleic Acids Res, 2023 Mar 21. PMID 36617428, Free PMC Article
    3. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Close P, et al. J Biol Chem, 2012 Sep 21. PMID 22854966, Free PMC Article
    4. Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. Freeman S, et al. EMBO Rep, 2019 Sep. PMID 31321879, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 6
    Names
    UPF0405 protein C3orf75 homolog
    elongator complex protein 6 homolog
    transmembrane protein 103

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081381.1 → NP_001074850.1  elongator complex protein 6

      See identical proteins and their annotated locations for NP_001074850.1

      Status: VALIDATED

      Source sequence(s)
      AK075986, BE448281, BM943556, CJ073544
      Consensus CDS
      CCDS52937.1
      UniProtKB/Swiss-Prot
      Q8BK75, Q9D0M9
      UniProtKB/TrEMBL
      A0A0H2UH13
      Related
      ENSMUSP00000142823.2, ENSMUST00000199592.5
      Conserved Domains (1) summary
      pfam09807
      Location:2 → 251
      ELP6; Elongation complex protein 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110133321..110151170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512297.1 → XP_006512360.1  elongator complex protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UH13
      Conserved Domains (1) summary
      pfam09807
      Location:21 → 268
      ELP6; Elongation complex protein 6

    RNA

    1. XR_003948016.2 RNA Sequence

    2. XR_001779017.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK75.1 GenPept UniProtKB/Swiss-Prot:Q8BK75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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