Adra1d adrenoceptor alpha 1D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adra1dprovided by RGD
Official Full Name: adrenoceptor alpha 1Dprovided by RGD
Primary source: RGD:62064
See related: Ensembl:ENSRNOG00000021256 AllianceGenome:RGD:62064
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adrd1
Summary: Enables alpha1-adrenergic receptor activity. Involved in aging; micturition; and positive regulation of vasoconstriction. Located in cytosol. Biomarker of polycystic ovary syndrome. Orthologous to human ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 35.2), Brain (RPKM 26.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (139246333..139262331, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (118793356..118809354, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (124129558..124145566, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antidepressants Differentially Regulate Intracellular Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro.
Title: Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
These results suggest that alpha-blockade reduces the urethral resistance associated with detrusor-sphincter dyssynergia, thus improving voiding efficiency in SCI rats.
Title: α1D-Adrenoceptor blockade increases voiding efficiency by improving external urethral sphincter activity in rats with spinal cord injury.
effects of female sexual hormones on the expression and function of alpha1A- and alpha1D-adrenoceptor subtypes in the late-pregnant rat myometrium
Title: The effects of female sexual hormones on the expression and function of α1A- and α1D-adrenoceptor subtypes in the late-pregnant rat myometrium.
Within 2 weeks of a burn, Adra1 expression increased in the re-forming epidermis, in dense bands of spindle-shaped cells in the upper dermis and on nerve fibres in the deep dermis. Adra1 expression in the upper dermis decreased contralateral to the burn.
Title: Up-regulation of cutaneous α1-adrenoceptors after a burn.
NA promotes HSC-T6 cell activation, proliferation and secretion of ECM in vitro via activation of Galpha-coupled alpha1B-AR and alpha1D-AR and the PKC-PI3K-AKT signaling pathway.
Title: Selective α1B- and α1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro.
Data suggest Adra1d expression is up-regulated in diabetic kidney; PPAR (peroxisome proliferator-activated receptor) activation (via PPAR alpha or gamma agonists as hypoglycemic agents) suppresses renal expression of Adra1d in diabetic nephropathy.
Title: Altered expression profile of renal α(1D)-adrenergic receptor in diabetes and its modulation by PPAR agonists.
The alpha(1D)-adrenergic receptor is involved in methamphetamine-induced hyperthermia and neurotoxicity.
Title: Involvement of the α(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats.
The effect of Ang II on a1B-AR mRNA seems to be influenced by the absence of a1D-AR in aortic smooth muscle cells.
Title: Angiotensin II modifies the expression of α(1)-adrenoceptors in aorta smooth muscle cells of α(1D)-adrenoceptor knockout mice.
activation of alpha(1D)-AR releases ATP, which induces P2X(7) receptors to increase [Ca(2+)](i) but not to stimulate protein secretion in lacrimal glands
Title: Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion.
pressor nerve responses in the pithed rat involve both alpha(1A) and alpha(1D)-adrenoceptor
Title: Vasopressor nerve responses in the pithed rat, previously identified as α2-adrenoceptor mediated, may be α1D-adrenoceptor mediated.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha1-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuron-glial cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1D adrenergic receptor

Names: RA42; adrenergic receptor delta1; adrenergic receptor, alpha 1d; adrenergic, alpha-1D-, receptor; alpha-1A adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024483.2 → NP_077809.2 alpha-1D adrenergic receptor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P23944, Q71UM4

UniProtKB/TrEMBL

A6HQE4, G3V8W0

Related

ENSRNOP00000028877.1, ENSRNOT00000028877.3

Conserved Domains (2) summary

cd14964
Location:92 → 118

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:91 → 407

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily