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    Miga2 mitoguardin 2 [ Mus musculus (house mouse) ]

    Gene ID: 108958, updated on 9-May-2024

    Summary

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    Official Symbol
    Miga2provided by MGI
    Official Full Name
    mitoguardin 2provided by MGI
    Primary source
    MGI:MGI:1922035
    See related
    Ensembl:ENSMUSG00000026858 AllianceGenome:MGI:1922035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam73b; C9orf54; 5730472N09Rik
    Summary
    Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Acts upstream of or within bone development. Predicted to be integral component of plasma membrane. Orthologous to human MIGA2 (mitoguardin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 26.5), mammary gland adult (RPKM 21.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 21.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30254232..30275532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30364233..30385520)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene protein phosphatase 2 protein activator Neighboring gene STARR-positive B cell enhancer ABC_E5903 Neighboring gene STARR-seq mESC enhancer starr_04096

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability. Gao Z, et al. Nat Commun, 2017 Nov 27. PMID 29180626, Free PMC Article
    2. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Liu XM, et al. Oncotarget, 2016 Jan 12. PMID 26716412, Free PMC Article
    3. Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation. Liu XM, et al. Endocrinology, 2017 Nov 1. PMID 28938432
    4. MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. Podrini C, et al. FASEB J, 2015 May. PMID 25526730
    5. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Zhang Y, et al. Mol Cell, 2016 Jan 7. PMID 26711011

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ovarian phenotypes of these mice suggested that the MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins.
      Title: Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
    2. Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile.
      Title: Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.
    3. Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
      Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitoguardin 2
    Names
    family with sequence similarity 73, member B
    mFLJ00199 protein
    ortholog of family with sequence similarity 73, member B FAM73B
    protein FAM73B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242407.2 → NP_001229336.1  mitoguardin 2 isoform 1

      See identical proteins and their annotated locations for NP_001229336.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS15880.1
      UniProtKB/Swiss-Prot
      A6PX05, Q3U4J7, Q3UST7, Q8BK03
      Related
      ENSMUSP00000077127.8, ENSMUST00000077977.14
      Conserved Domains (1) summary
      pfam10265
      Location:31 → 568
      DUF2217; Uncharacterized conserved protein (DUF2217)

    2. NM_001378906.1 → NP_001365835.1  mitoguardin 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Conserved Domains (1) summary
      pfam10265
      Location:31 → 529
      Miga; Mitoguardin

    3. NM_001378907.1 → NP_001365836.1  mitoguardin 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Conserved Domains (1) summary
      pfam10265
      Location:31 → 529
      Miga; Mitoguardin

    4. NM_001378909.1 → NP_001365838.1  mitoguardin 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Conserved Domains (1) summary
      pfam10265
      Location:30 → 377
      Miga; Mitoguardin

    5. NM_001378911.1 → NP_001365840.1  mitoguardin 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Conserved Domains (1) summary
      pfam10265
      Location:30 → 377
      Miga; Mitoguardin

    6. NM_001407284.1 → NP_001394213.1  mitoguardin 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954388

    7. NM_175392.3 → NP_780601.1  mitoguardin 2 isoform 1

      See identical proteins and their annotated locations for NP_780601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC051404
      Consensus CDS
      CCDS15880.1
      UniProtKB/Swiss-Prot
      A6PX05, Q3U4J7, Q3UST7, Q8BK03
      Related
      ENSMUSP00000097787.4, ENSMUST00000100214.10
      Conserved Domains (1) summary
      pfam10265
      Location:31 → 568
      DUF2217; Uncharacterized conserved protein (DUF2217)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30254232..30275532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497594.2 → XP_006497657.1  mitoguardin 2 isoform X2

      Conserved Domains (1) summary
      pfam10265
      Location:117 → 615
      Miga; Mitoguardin

    2. XM_030246575.1 → XP_030102435.1  mitoguardin 2 isoform X3

      Conserved Domains (1) summary
      pfam10265
      Location:30 → 377
      Miga; Mitoguardin

    RNA

    1. XR_003949993.2 RNA Sequence

    2. XR_003949994.2 RNA Sequence

    3. XR_866005.2 RNA Sequence

    4. XR_003949995.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK03.1 GenPept UniProtKB/Swiss-Prot:Q8BK03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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