PARP4 poly(ADP-ribose) polymerase family member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PARP4provided by HGNC
Official Full Name: poly(ADP-ribose) polymerase family member 4provided by HGNC
Primary source: HGNC:HGNC:271
See related: Ensembl:ENSG00000102699 MIM:607519; AllianceGenome:HGNC:271
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1
Summary: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in colon (RPKM 22.5), small intestine (RPKM 20.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q12.12

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (24420931..24512778, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (23628369..23720247, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (24995069..25086916, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Title: Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance.
Title: Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance.
Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level.
Title: Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level.
MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.
Title: MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.
Modification of PARP4, XRCC3, and RAD51 Gene Polymorphisms on the Relation between Bisphenol A Exposure and Liver Abnormality.
Title: Modification of PARP4, XRCC3, and RAD51 Gene Polymorphisms on the Relation between Bisphenol A Exposure and Liver Abnormality.
our results do not support that PARP4 functions as a cancer susceptibility gene. This study highlights the importance of performing functional analyses for candidate cancer predisposition genes.
Title: Assessment of PARP4 as a candidate breast cancer susceptibility gene.
Germline intronic PARP4 variants could be a risk factor for the development of TC.
Title: Genetic variants of PARP4 gene and PARP4P2 pseudogene in patients with multiple primary tumors including thyroid cancer.
poly [ADPribose] polymerase(PARP)4 was identified as a novel cancer stemnessassociated gene in esophageal squamous cell carcinoma (ESCC) and its association with survival was validated in a cohort of 121 patients with ESCC
Title: Single‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer.
Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity
Title: vPARP Adjusts MVP Expression in Drug-resistant Cell Lines in Conjunction with MDR Proteins.
PARP4 is a possible susceptibility gene of primary thyroid and breast cancer
Title: Germline PARP4 mutations in patients with primary thyroid and breast cancers.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with poly (ADP-ribose) polymerase family, member 4 (PARP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
	gag-pol	Inhibition of HIV-1 protease by saquinavir and leu3.a blocks PARP cleavage and protects cells from apoptosis and necrosis	PubMed
	gag-pol	HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH25392 (e-PCR)
- UniSTS:17217

STS-H65490 (e-PCR)
- UniSTS:25717

RH44582 (e-PCR)
- UniSTS:29304

G33050 (e-PCR)
- UniSTS:117627

SHGC-3231 (e-PCR)
- UniSTS:43699

SHGC-58546 (e-PCR)
- UniSTS:94391

WI-17731 (e-PCR)
- UniSTS:50374

A010A27 (e-PCR)
- UniSTS:29913

RH44920 (e-PCR)
- UniSTS:29933

RH68557 (e-PCR)
- UniSTS:47092

D13S980 (e-PCR)
- UniSTS:152314

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables NAD+-protein ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	NAS Non-traceable Author Statement more info	PubMed
involved_in DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of telomerase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of ribonucleoprotein complex	NAS Non-traceable Author Statement more info	PubMed
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP4

Names: 193 kDa vault protein; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1; ADP-ribosyltransferase diphtheria toxin-like 4; H5 proline-rich; I-alpha-I-related; PARP-related; PARP-related/IalphaI-related H5/proline-rich; poly [ADP-ribose] polymerase 4; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase-like 1; vault poly(ADP-ribose) polymerase; vault protein, 193-kDa; von Willebrand factor A domain containing 5C

NP_006428.2

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006437.4 → NP_006428.2 protein mono-ADP-ribosyltransferase PARP4

See identical proteins and their annotated locations for NP_006428.2

Status: REVIEWED

Source sequence(s)

AF158255, AL359763, BX479127, CA308288, CV574448, DB238428, T10289

Consensus CDS

CCDS9307.1

UniProtKB/Swiss-Prot

O75903, Q14682, Q5QNZ9, Q9H1M6, Q9UKK3

Related

ENSP00000371419.3, ENST00000381989.4

Conserved Domains (5) summary

cd01437
Location:251 → 565

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

TIGR03788
Location:636 → 1184

marine_srt_targ; marine proteobacterial sortase target protein

pfam15822
Location:1308 → 1462

MISS; MAPK-interacting and spindle-stabilizing protein-like

cd17726
Location:5 → 88

BRCT_PARP4_like; BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins

pfam08487
Location:623 → 733

VIT; Vault protein inter-alpha-trypsin domain