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    ZNF101 zinc finger protein 101 [ Homo sapiens (human) ]

    Gene ID: 94039, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF101provided by HGNC
    Official Full Name
    zinc finger protein 101provided by HGNC
    Primary source
    HGNC:HGNC:12881
    See related
    Ensembl:ENSG00000181896 MIM:603983; AllianceGenome:HGNC:12881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZF12
    Summary
    Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]
    Expression
    Broad expression in lymph node (RPKM 7.9), appendix (RPKM 4.5) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19p13.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19668153..19683506)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19805664..19821015)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19778962..19794315)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19739417-19740339 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19753343-19754298 Neighboring gene GEM interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10453 Neighboring gene ATPase 13A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19772231-19772878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19773833-19774815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10455 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19779337-19779903 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19779904-19780469 Neighboring gene zinc finger protein 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10457 Neighboring gene uncharacterized LOC101060187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19858409-19858910 Neighboring gene sorting nexin 18 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins. Looman C, et al. Mamm Genome, 2004 Jan. PMID 14727140
    2. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Dehal P, et al. Science, 2001 Jul 6. PMID 11441184
    3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
    4. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Aulchenko YS, et al. Nat Genet, 2009 Jan. PMID 19060911, Free PMC Article
    5. Genome-wide association study of selenium concentrations. Cornelis MC, et al. Hum Mol Genet, 2015 Mar 1. PMID 25343990, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog
    Genome-wide association study of selenium concentrations.
    EBI GWAS Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149565, MGC149566, DKFZp570I0164

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 101
    Names
    zinc finger protein 101 (Y2)
    zinc finger protein 12
    zinc finger protein HZF12

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300949.2 → NP_001287878.1  zinc finger protein 101 isoform 2

      See identical proteins and their annotated locations for NP_001287878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC011458, AY149174, BM972114, DB264378
      Consensus CDS
      CCDS77271.1
      UniProtKB/Swiss-Prot
      Q8IZC7
      Conserved Domains (2) summary
      COG5048
      Location:56 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_033204.4 → NP_149981.2  zinc finger protein 101 isoform 1

      See identical proteins and their annotated locations for NP_149981.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC011458, AY149174, BM972114, CR999939
      Consensus CDS
      CCDS32971.1
      UniProtKB/Swiss-Prot
      C9JU83, Q0VDG9, Q8IZC7
      Related
      ENSP00000468049.1, ENST00000592502.2
      Conserved Domains (6) summary
      cd11674
      Location:149 → 209
      lambda-1; inner capsid protein lambda-1 or VP3
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:176 → 357
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:340 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:240 → 264
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      19668153..19683506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439723.1 → XP_047295679.1  zinc finger protein 101 isoform X2

      Related
      ENSP00000400952.2, ENST00000415784.6

    2. XM_047439722.1 → XP_047295678.1  zinc finger protein 101 isoform X1

    3. XM_024451785.2 → XP_024307553.1  zinc finger protein 101 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:56 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      19805664..19821015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322682.1 → XP_054178657.1  zinc finger protein 101 isoform X5

    2. XM_054322680.1 → XP_054178655.1  zinc finger protein 101 isoform X3

    3. XM_054322681.1 → XP_054178656.1  zinc finger protein 101 isoform X4

    4. XM_054322683.1 → XP_054178658.1  zinc finger protein 101 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZC7.1 GenPept UniProtKB/Swiss-Prot:Q8IZC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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