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    Pla2g4d phospholipase A2, group IVD [ Mus musculus (house mouse) ]

    Gene ID: 78390, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pla2g4dprovided by MGI
    Official Full Name
    phospholipase A2, group IVDprovided by MGI
    Primary source
    MGI:MGI:1925640
    See related
    Ensembl:ENSMUSG00000070719 AllianceGenome:MGI:1925640
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pla2delta; cPLA2delta; 2610311B01Rik
    Summary
    Enables phospholipase A2 activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to act upstream of or within lipid catabolic process. Located in cytoplasm. Orthologous to human PLA2G4D (phospholipase A2 group IVD). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 4.0), testis adult (RPKM 3.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 60.31 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120096347..120119678, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120265866..120289069, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene EH-domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_05504 Neighboring gene STARR-positive B cell enhancer ABC_E226 Neighboring gene phospholipase A2, group IVE Neighboring gene predicted gene, 52575 Neighboring gene STARR-seq mESC enhancer starr_05506 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVF Neighboring gene VPS39 HOPS complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120178706-120178815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A(2) coordinates acute wound healing and repair. MacKnight HP, et al. Sci Signal, 2019 Dec 3. PMID 31796632, Free PMC Article
    2. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, et al. J Biol Chem, 2005 Jul 1. PMID 15866882
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair.
      Title: The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A(2) coordinates acute wound healing and repair.
    2. murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
      Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic phospholipase A2 delta
    Names
    cPLA2-delta
    NP_001019308.1
    XP_006500476.1
    XP_011238151.1
    XP_036018615.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024137.1 → NP_001019308.1  cytosolic phospholipase A2 delta

      See identical proteins and their annotated locations for NP_001019308.1

      Status: PROVISIONAL

      Source sequence(s)
      AB195276
      Consensus CDS
      CCDS16617.1
      UniProtKB/Swiss-Prot
      A2AQJ1, Q3TJC5, Q50L43
      UniProtKB/TrEMBL
      Q14CI2
      Related
      ENSMUSP00000092252.5, ENSMUST00000094665.5
      Conserved Domains (3) summary
      cd04036
      Location:32 → 151
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:283 → 758
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
      cl11396
      Location:278 → 814
      Patatin_and_cPLA2; Patatins and Phospholipases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120096347..120119678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500413.5 → XP_006500476.1  cytosolic phospholipase A2 delta isoform X1

      UniProtKB/TrEMBL
      Q14CI2, Q14DK8
      Conserved Domains (2) summary
      pfam18695
      Location:24 → 131
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:130 → 666
      Patatin_and_cPLA2; Patatins and Phospholipases

    2. XM_011239849.3 → XP_011238151.1  cytosolic phospholipase A2 delta isoform X2

      Conserved Domains (2) summary
      pfam18695
      Location:5 → 95
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:94 → 630
      Patatin_and_cPLA2; Patatins and Phospholipases

    3. XM_036162722.1 → XP_036018615.1  cytosolic phospholipase A2 delta isoform X3

      Conserved Domains (3) summary
      cd04036
      Location:32 → 151
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:172 → 279
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:278 → 633
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q50L43.3 GenPept UniProtKB/Swiss-Prot:Q50L43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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