OASL 2'-5'-oligoadenylate synthetase like [Homo sapiens (human)] - Gene

Summary

Official Symbol: OASLprovided by HGNC
Official Full Name: 2'-5'-oligoadenylate synthetase likeprovided by HGNC
Primary source: HGNC:HGNC:8090
See related: Ensembl:ENSG00000135114 MIM:603281; AllianceGenome:HGNC:8090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
Summary: Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues See more
Orthologs: all
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Genomic context

Location:: 12q24.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (121017761..121039246, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (121007355..121028848, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (121455564..121477049, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OASL regulates pro-inflammatory mediators such as cytokines and chemokines which suppress intracellular mycobacterial growth and survival.
Title: 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion.
these resulta define distinct mechanisms by which OASL differentially regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feedback regulator of cGAS
Title: Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
These data uncover a promycobacterial role for STING-dependent OASL production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen.
Title: STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.
OASL acts as a cellular antiviral protein and RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
Title: 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.
Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes.
Title: Differential upregulation of human 2'5'OAS genes on systemic sclerosis: Detection of increased basal levels of OASL and OAS2 genes through a qPCR based assay.
these findings show a mechanism by which human OASL contributes to host antiviral responses by enhancing RIG-I activation.
Title: Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors
Title: Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling.
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
Title: Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein.
Title: Differential regulation of the OASL and OAS1 genes in response to viral infections.
The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls.
Title: [Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus].

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1&#x003b1; as a master regulator of plasma protein fucosylation. EBI GWAS Catalog EBI GWAS CatalogPubMed
New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of 2'-5'-oligoadenylate synthetase-like (OASL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of 2'-5'-oligoadenylate synthetase-like (OASL; p59-OASL) in immature dendritic cells and monocyte-derived macrophages	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of OASL in human monocyte-derived dendritic cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC229255P2 (e-PCR)
- UniSTS:272169

G64627 (e-PCR)
- UniSTS:163889

PGOS06b (e-PCR)
- UniSTS:466009

RH65656 (e-PCR)
- UniSTS:55913

NoName (e-PCR)
- UniSTS:486378

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear thyroid hormone receptor binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of RIG-I signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase-like protein

Names: 2'-5'-OAS-RP; 2'-5'-OAS-related protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; TR-interacting protein 14; thyroid receptor-interacting protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001261825.2 → NP_001248754.1 2'-5'-oligoadenylate synthase-like protein isoform c

See identical proteins and their annotated locations for NP_001248754.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC079602

Consensus CDS

CCDS73536.1

UniProtKB/Swiss-Prot

Q15646

Related

ENSP00000479512.1, ENST00000620239.5

Conserved Domains (5) summary

cd05400
Location:29 → 212

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

smart00213
Location:304 → 372

UBQ; Ubiquitin homologues

pfam00240
Location:309 → 375

ubiquitin; Ubiquitin family

pfam10421
Location:167 → 219

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

cl00155
Location:224 → 303

UBQ; Ubiquitin-like proteins
NM_001395418.1 → NP_001382347.1 2'-5'-oligoadenylate synthase-like protein isoform b

Status: VALIDATED

Source sequence(s)

AC079602

Consensus CDS

CCDS9212.1

Related

ENSP00000444127.2, ENST00000543677.2

Conserved Domains (2) summary

cd05400
Location:29 → 212

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:168 → 219

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
NM_001395419.1 → NP_001382348.1 2'-5'-oligoadenylate synthase-like protein isoform d

Status: VALIDATED

Source sequence(s)

AC079602

Consensus CDS

CCDS91762.1

UniProtKB/TrEMBL

A0A7P0T9H8, A0A7P0TB39

Related

ENSP00000505685.1, ENST00000680620.1

Conserved Domains (2) summary

cd05400
Location:29 → 212

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:168 → 349

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
NM_003733.4 → NP_003724.1 2'-5'-oligoadenylate synthase-like protein isoform a

See identical proteins and their annotated locations for NP_003724.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC079602

Consensus CDS

CCDS9211.1

UniProtKB/Swiss-Prot

B2RAZ2, I1YDD2, O75686, Q15646, Q17R95, Q9Y6K6, Q9Y6K7

UniProtKB/TrEMBL

B3KN79

Related

ENSP00000257570.4, ENST00000257570.10

Conserved Domains (4) summary

cd05400
Location:29 → 212

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

cd01811
Location:354 → 433

OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2

pfam00240
Location:436 → 506

ubiquitin; Ubiquitin family

pfam10421
Location:168 → 351

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
NM_198213.3 → NP_937856.1 2'-5'-oligoadenylate synthase-like protein isoform b

See identical proteins and their annotated locations for NP_937856.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC079602

Consensus CDS

CCDS9212.1

UniProtKB/Swiss-Prot

Q15646

Related

ENSP00000341125.5, ENST00000339275.10

Conserved Domains (2) summary

cd05400
Location:29 → 212

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:168 → 219

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus