S100A12 S100 calcium binding protein A12 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: S100A12provided by VGNC
Official Full Name: S100 calcium binding protein A12provided by VGNC
Primary source: VGNC:VGNC:59189
See related: BGD:BT11315; Ensembl:ENSBTAG00000012638
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CAGC; CAAF1; CO-AG; EN-RAGE
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (17102730..17104176)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the S100A12 level in milk may serve as a diagnostic tool for subclinical mastitis in cows without obvious clinical signs.
Title: S100 calcium-binding protein A12 as a diagnostic index for subclinical mastitis in cows.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RAGE receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein S100-A12

Names: RAGE-binding protein; calcium-binding protein in amniotic fluid 1; calgranulin-C; cornea-associated antigen; extracellular newly identified RAGE-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174651.3 → NP_777076.1 protein S100-A12

See identical proteins and their annotated locations for NP_777076.1

Status: PROVISIONAL

Source sequence(s)

BC102542

UniProtKB/Swiss-Prot

P79105, Q3T070, Q9TR16

UniProtKB/TrEMBL

B6VAP8

Conserved Domains (1) summary

cd05030
Location:2 → 89

calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

17102730..17104176

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005203612.3 → XP_005203669.1 protein S100-A12 isoform X1

See identical proteins and their annotated locations for XP_005203669.1

UniProtKB/Swiss-Prot

P79105, Q3T070, Q9TR16

UniProtKB/TrEMBL

B6VAP8

Related

ENSBTAP00000056088.3, ENSBTAT00000063314.3

Conserved Domains (1) summary

cd05030
Location:2 → 89

calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...