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    NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 64859, updated on 7-Apr-2024

    Summary

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    Official Symbol
    NABP1provided by HGNC
    Official Full Name
    nucleic acid binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:26232
    See related
    Ensembl:ENSG00000173559 MIM:612103; AllianceGenome:HGNC:26232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSB2; OBFC2A; SOSS-B2; NABP1-OT1
    Summary
    Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
    Expression
    Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q32.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (191678136..191686943)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (192167017..192175824)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192542862..192551669)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985833 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192406286-192406448 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:192428730-192429929 Neighboring gene Sharpr-MPRA regulatory region 3391 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5925 Neighboring gene uncharacterized LOC124905959 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192510916-192511055 Neighboring gene Sharpr-MPRA regulatory region 14503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:192542703-192543205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12197 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:192544033-192545232 Neighboring gene uncharacterized LOC124900605 Neighboring gene uncharacterized LOC124908062

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Novel lncRNA, AK130181, Contributes to HIV-1 Latency by Regulating Viral Promoter-Driven Gene Expression in Primary CD4(+) T Cells. Li H, et al. Mol Ther Nucleic Acids, 2020 Jun 5. PMID 32408053, Free PMC Article
    2. hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage. Boucher D, et al. Sci Rep, 2021 Oct 12. PMID 34642383, Free PMC Article
    3. DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival. Shen Z, et al. Oncotarget, 2016 Nov 29. PMID 27793000, Free PMC Article
    4. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. Li Y, et al. J Biol Chem, 2009 Aug 28. PMID 19605351, Free PMC Article
    5. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Richard DJ, et al. Nature, 2008 May 29. PMID 18449195

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
      Title: hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
    2. SNPs rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were associated with survival in laryngeal squamous cell carcinoma patients.
      Title: DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival.
    3. hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response.
      Title: HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ13624, FLJ22833, FLJ26671, MGC111163, DKFZp667M1322

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2/M transition checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic G2/M transition checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SOSS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SOSS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SOSS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SOSS complex subunit B2
    Names
    NABP1 3'UTR overlapping transcript 1
    lncRNA AK130181
    oligonucleotide/oligosaccharide-binding fold containing 2A
    oligonucleotide/oligosaccharide-binding fold-containing protein 2A
    sensor of single-strand DNA complex subunit B2
    sensor of ssDNA subunit B2
    single-stranded DNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031716.5 → NP_001026886.1  SOSS complex subunit B2 isoform 1

      See identical proteins and their annotated locations for NP_001026886.1

      Status: VALIDATED

      Source sequence(s)
      AC114778
      Consensus CDS
      CCDS33352.1
      UniProtKB/Swiss-Prot
      Q658Y8, Q96AH0, Q9H5X6
      UniProtKB/TrEMBL
      H7C0W4
      Related
      ENSP00000403683.2, ENST00000425611.9
      Conserved Domains (1) summary
      cd04491
      Location:22 → 99
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    2. NM_001254736.3 → NP_001241665.1  SOSS complex subunit B2 isoform 2

      See identical proteins and their annotated locations for NP_001241665.1

      Status: VALIDATED

      Source sequence(s)
      AC114778
      Consensus CDS
      CCDS58745.1
      UniProtKB/Swiss-Prot
      Q96AH0
      Related
      ENSP00000387243.1, ENST00000410026.7

    RNA

    1. NR_045622.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114778
      Related
      ENST00000307834.9

    2. NR_045623.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114778

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      191678136..191686943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445531.1 → XP_047301487.1  SOSS complex subunit B2 isoform X1

    2. XM_047445532.1 → XP_047301488.1  SOSS complex subunit B2 isoform X1

      Related
      ENSP00000390901.1, ENST00000451500.5

    RNA

    1. XR_007080680.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      192167017..192175824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343422.1 → XP_054199397.1  SOSS complex subunit B2 isoform X1

    2. XM_054343423.1 → XP_054199398.1  SOSS complex subunit B2 isoform X1

    RNA

    1. XR_008486492.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_131917.1: Suppressed sequence

      Description
      NR_131917.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96AH0.1 GenPept UniProtKB/Swiss-Prot:Q96AH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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