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    Rexo1 RNA exonuclease 1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314630, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rexo1provided by RGD
    Official Full Name
    RNA exonuclease 1 homologprovided by RGD
    Primary source
    RGD:1309872
    See related
    Ensembl:ENSRNOG00000017916 AllianceGenome:RGD:1309872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tceb3bp1
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 52.9), Testes (RPKM 47.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9804740..9824717)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9154050..9174035)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12022268..12041660)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 17A, depalmitoylase Neighboring gene KLF transcription factor 16 Neighboring gene uncharacterized LOC120093775 Neighboring gene uncharacterized LOC134479810 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene one cut homeobox 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease 1 homolog
    Names
    REX1, RNA exonuclease 1 homolog
    transcription elongation factor B polypeptide 3 binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012114.3 → NP_001012114.2  RNA exonuclease 1 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8J6, D3ZCX6
      Related
      ENSRNOP00000024080.5, ENSRNOT00000024080.7
      Conserved Domains (2) summary
      cd06145
      Location:1037 → 1185
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:778 → 938
      EloA-BP1; ElonginA binding-protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9804740..9824717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263421.1 → XP_063119491.1  RNA exonuclease 1 homolog isoform X1

    RNA

    1. XR_005486604.2 RNA Sequence

    2. XR_005486605.2 RNA Sequence

    3. XR_010052967.1 RNA Sequence

    4. XR_005486606.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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