Nes nestin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nesprovided by RGD
Full Name: nestinprovided by RGD
Primary source: RGD:3162
See related: Ensembl:ENSRNOG00000018681 AllianceGenome:RGD:3162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 155.9), Lung (RPKM 113.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (175735715..175745631)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (173437867..173447777)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (187343109..187352972)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nestin Regulates Muller Glia Proliferation After Retinal Injury.
Title: Nestin Regulates Müller Glia Proliferation After Retinal Injury.
Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
Title: Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
Title: Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
Title: Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
Title: Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
Title: Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
In the chronic hypoxia/SU5416 animal model of pulmonary hypertension, Nestin+ endothelial cells were found in occlusive pulmonary vascular lesions.
Title: Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension.
Abundant nestin was present in tanycyte cell bodies and processes and also was observed in patches of ependymal cells as well as in isolated ependymal cells throughout the walls of the 3rdV
Title: Nestin expression and in vivo proliferative potential of tanycytes and ependymal cells lining the walls of the third ventricle in the adult rat brain.
Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells
Title: Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells.
In this study, we established stable, nestin promoter-driven tv-a (Ntv-a) transgenic rats. We then introduced the gene transformations previously shown to induce proneural-like brain tumors in mice, and characterized tumor initiation and progression using MRI and MR spectroscopy (MRS).
Title: Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.

Submit: New GeneRIF Correction See all GeneRIFs (69)

General gene information

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Markers

UniSTS:497298 (e-PCR)
- UniSTS:497298

Nes (e-PCR), detects polymorphism
- UniSTS:497298

AA166324 (e-PCR), detects polymorphism
- UniSTS:143032

RH131466 (e-PCR)
- UniSTS:214749

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR5 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR5 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables intermediate filament binding	IEA Inferred from Electronic Annotation more info
enables intermediate filament binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of intermediate filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intermediate filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308239.1 → NP_001295168.1 nestin isoform 1

See identical proteins and their annotated locations for NP_001295168.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P21263, Q8CJ14

UniProtKB/TrEMBL

A6J639, G3V8F8

Related

ENSRNOP00000025314.2, ENSRNOT00000025314.4

Conserved Domains (2) summary

COG5410
Location:1504 → 1610

COG5410; Uncharacterized protein [Function unknown]

pfam00038
Location:7 → 313

Filament; Intermediate filament protein
NM_012987.2 → NP_037119.2 nestin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6ABC1, A6J640

Related

ENSRNOP00000089157.1, ENSRNOT00000100350.1

Conserved Domains (3) summary

PTZ00121
Location:469 → 841

PTZ00121; MAEBL; Provisional

pfam17380
Location:700 → 1026

DUF5401; Family of unknown function (DUF5401)

pfam00038
Location:7 → 313

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

175735715..175745631

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017590648.3 → XP_017446137.1 nestin isoform X1

UniProtKB/Swiss-Prot

P21263, Q8CJ14

UniProtKB/TrEMBL

A6J639, G3V8F8

Conserved Domains (2) summary

COG5410
Location:1504 → 1610

COG5410; Uncharacterized protein [Function unknown]

pfam00038
Location:7 → 313

Filament; Intermediate filament protein